Evidence map›Paper›PMID 31289619›Full record

ArticleOncotarget2019

Detecting predictive androgen receptor modifications in circulating prostate cancer cells.

Julie Steinestel, Manuel Luedeke, Annette Arndt, Thomas J Schnoeller, Jochen K Lennerz, Carina Wurm, Christiane Maier, Marcus V Cronauer, Konrad Steinestel, Andres J Schrader

Open access · diamondAbstract read
In one paragraph

Article in Oncotarget, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
94citing papers in PubMed, 3 pooled it
23.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

94 citing papers in PubMed, 3 syntheses or guidelines pooled it, 161 citations in OpenAlex.

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  4. Expression of AR-V7 and ARvClinical cancer research : an official journal of the American Association for Cancer Research · 2019
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34 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Julie Steinestel *Clinic of Urology, University Hospital Ulm, Ulm, Germany.
Manuel Luedeke *Clinic of Urology, University Hospital Ulm, Ulm, Germany.
Annette Arndt *Institute of Pathology and Molecular Pathology, Bundeswehrkrankenhaus Ulm, Ulm, Germany.
Thomas J SchnoellerClinic of Urology, University Hospital Ulm, Ulm, Germany.
Jochen K LennerzMassachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
Carina WurmClinic of Urology, University Hospital Ulm, Ulm, Germany.
Christiane MaierClinic of Urology, University Hospital Ulm, Ulm, Germany.
Marcus V CronauerClinic of Urology, University Hospital Ulm, Ulm, Germany.
Konrad SteinestelGerhard-Domagk Institute of Pathology, University of Muenster, Muenster, Germany.
Andres J SchraderClinic of Urology, University Hospital Ulm, Ulm, Germany.
University Hospital Ulm · DEBundeswehrkrankenhaus · DEMassachusetts General Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Molecular modifications of the androgen receptor (AR) can cause resistance to androgen deprivation therapy (ADT) in prostate cancer patients. Since lack of representative tumor samples hinders therapy adjustments according to emerging AR-modifications, we evaluated simultaneous detection of the two most common AR modifications (AR-V7 splice variant and

Indexed as

androgen receptor modificationcastration-resistant prostate cancercirculating tumor cellssplice variants

Identifiers

PMID31289619
PMCPMC6609250
OpenAlexW1925305957

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.