ArticleAdvanced synthesis & catalysis2018
Organocatalytic Decarboxylative Cyanomethylation of Difluoromethyl and Trifluoromethyl Ketones.
Article in Advanced synthesis & catalysis, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed.
- Enantioseparation and racemization of 3-fluorooxindoles.Chirality · 2023Article
- Selective CspSynthesis · 2022Article
- Article
- Palladium and Nickel Catalyzed Suzuki Cross-Coupling with Alkyl Fluorides.Organic letters · 2021Article
- A computational study for the reaction mechanism of metal-free cyanomethylation of aryl alkynoates with acetonitrile.RSC advances · 2021Article
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Authors and funding
3 authors.
Funding
Abstract
An efficient organocatalytic method for the synthesis of difluoromethyl and trifluoromethyl substituted β-hydroxynitriles is introduced. The decarboxylative cyanomethylation of fluorinated ketones with readily available cyanoacetic acid gives a variety of tertiary alcohols in high yields and without concomitant water elimination. The reaction occurs in the presence of catalytic amounts of triethylamine, can be upscaled and applied to chlorofluoromethyl ketones and difluoromethyl ketimines.
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Registered trials
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