Evidence map›Paper›PMID 31289370›Full record

ReviewNature reviews. Immunology2019

Sleep and inflammation: partners in sickness and in health.

Michael R Irwin

3 registry-linked trialsAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 568 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
568citing papers in PubMed, 9 pooled it
48.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05732064 phase4completednot on this mapstarted 2023, after this paper: background citation

Effects of Low-dose Dexmedetomidine-esketamine Combined Nasal Administration at Night on Perioperative Sleep Quality in Breast Cancer Patients: a Randomized, Double-blind, Placebo-controlled Trial

TypeinterventionalSponsorPeking University First HospitalRan2023 to 2025Enrolled180ConditionsBreast Cancer, Perioperative Period, Dexmedetomidine, EsketamineArmsDexmedetomidine, Esketamine, Normal saline
NCT05950646 phase4completednot on this mapstarted 2024, after this paper: background citation

Effect of Mini-dose Dexmedetomidine-Esketamine Infusion on Sleep Quality in Older Patients Undergoing Knee or Hip Replacement Surgery: A Multicenter Randomized Controlled Trial

TypeinterventionalSponsorPeking University First HospitalRan2024 to 2026Enrolled154ConditionsOld Age, Knee Replacement Surgery, Hip Replacement Surgery, DexmedetomidineArmsDexmedetomidine, Esketamine, Normal saline
NCT07610343 phase4not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Impact of Intranasal Dexmedetomidine-esketamine on Sleep Quality and Cognitive Function in Older Adults With Mild-to-moderate Cognitive Impairment: a Randomized, Double-blind, and Placebo-controlled Trial

TypeinterventionalSponsorPeking University First HospitalRan2026 to 2027Enrolled60ConditionsOlder Adults, Cognitive Impairment, Sleep Disorders, DexmedetomidineArmsDexmedetomidine-esketamine combination, Placebo
3 · Its place in the literature

Who cites it

568 citing papers in PubMed, 9 syntheses or guidelines pooled it, 892 citations in OpenAlex.

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  14. Integrated sleep and psychological interventions enhance postoperative recovery and quality of life in colorectal cancer: a randomized controlled trial.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
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  18. Exploring Factors Associated with Sleep Quality After Lung Transplantation.Progress in transplantation (Aliso Viejo, Calif.) · 2025
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508 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Michael R IrwinJane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA. mirwin1@ucla.edu.ORCID http://orcid.org/0000-0002-1502-8431
University of Southern California · US

Funding

Aging: Sleep and Inflammatory Mechanisms in Depression PreventionR01AG026364 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI IRWIN, MICHAEL R · 2005 to 2015
$5.8M
Sleep, Inflamation, and Depression Occurrence in Breast Cancer SurvivorsR01CA160245 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI IRWIN, MICHAEL R · 2012 to 2016
$3.9M
Mindfulness Meditation and Insomnia in Alzheimer Disease Caregivers: Inflammatory and Biological Aging MechanismsR01AG056424 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI IRWIN, MICHAEL R · 2017 to 2021
$3.7M
Experimental model of chronic pain risk: Insomnia, inflammation, central sensitization, and affective disturbanceR01AG057750 · NIA · JOHNS HOPKINS UNIVERSITY · PI SMITH, MICHAEL T · 2018 to 2022
$3.4M
Sleep Disturbance, Inflammation, and Cellular Aging in Breast Cancer SurvivorsR01CA207130 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HAQUE, REINA, IRWIN, MICHAEL R · 2016 to 2020
$3.2M
Experimental Model of Depression in Aging: Insomnia, Inflammation, and Affect MechanismsR01AG051944 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI IRWIN, MICHAEL R · 2016 to 2020
$3.0M
NCI NIH HHS R01 CA160245NCI NIH HHS R01 CA207130NIA NIH HHS R01 AG026364NIA NIH HHS R01 AG051944NIA NIH HHS R01 AG056424NIA NIH HHS R01 AG057750
6 · The paper itself

Abstract

The discovery of reciprocal connections between the central nervous system, sleep and the immune system has shown that sleep enhances immune defences and that afferent signals from immune cells promote sleep. One mechanism by which sleep is proposed to provide a survival advantage is in terms of supporting a neurally integrated immune system that might anticipate injury and infectious threats. However, in modern times, chronic social threats can drive the development of sleep disturbances in humans, which can contribute to the dysregulation of inflammatory and antiviral responses. In this Review, I describe our current understanding of the relationship between sleep dynamics and host defence mechanisms, with a focus on cytokine responses, the neuroendocrine and autonomic pathways that connect sleep with the immune system and the role of inflammatory peptides in the homeostatic regulation of sleep. Furthermore, I discuss the therapeutic potential of harnessing these reciprocal mechanisms of sleep-immune regulation to mitigate the risk of inflammatory and infectious diseases.

Indexed as

CytokinesHumansHypothalamo-Hypophyseal SystemInflammationSleepSleep Wake DisordersSympathetic Nervous SystemCytokines

Identifiers

PMID31289370
OpenAlexW2960982983

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.