Coumamarin: a first coumarinyl calcium complex isolated from nature.

Abdelaaty Hamed, Ahmed S Abdel-Razek, Marcel Frese, Jens Sproß, Hans Georg Stammler, Norbert Sewald, Mohamed Shaaban

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Article in The Journal of antibiotics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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7 authors.

Abdelaaty HamedOrganic and Bioorganic Chemistry, Department of Chemistry, Bielefeld University, Universitätsstraße 25, 33501, Bielefeld, Germany.ORCID http://orcid.org/0000-0003-4119-7447

Ahmed S Abdel-RazekOrganic and Bioorganic Chemistry, Department of Chemistry, Bielefeld University, Universitätsstraße 25, 33501, Bielefeld, Germany.

Marcel FreseOrganic and Bioorganic Chemistry, Department of Chemistry, Bielefeld University, Universitätsstraße 25, 33501, Bielefeld, Germany.

Jens SproßChair of Industrial Organic Chemistry and Biotechnology, Faculty of Chemistry, Bielefeld University, Bielefeld, Germany.

Hans Georg StammlerDepartment of Chemistry, Inorganic and Structural Chemistry, Bielefeld University, 33501, Bielefeld, Germany.

Norbert SewaldOrganic and Bioorganic Chemistry, Department of Chemistry, Bielefeld University, Universitätsstraße 25, 33501, Bielefeld, Germany.

Mohamed ShaabanOrganic and Bioorganic Chemistry, Department of Chemistry, Bielefeld University, Universitätsstraße 25, 33501, Bielefeld, Germany. mshaaba@gmail.com.ORCID http://orcid.org/0000-0001-9281-2505

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The first calcium complex from nature, Coumamarin (1), 7-hydroxy-3-methoxy-2-oxo-2H-chromene-6-carboxylate Ca(II) complex, was isolated from Aspergillus sydowii ASTI, together with diorcinol (2), violaceol I (3), hydroxysydonic acid (4), cyclo (Trp-Phe), kojic acid, ergosterol, and uracil. The producing strain was isolated from marine water sample collected from Tiran Island, Red Sea, Egypt. Structure 1 was assigned by intensive 1D, 2D NMR, HR-ESIMS, and X-ray crystallography as well. Coumamarin is potentially active against certain tested bacteria and yeasts, while showing no cytotoxic activity against human cervix carcinoma cell line (KB-3-1). Taxonomically, the fungus was identified by phylogenetic analysis of its 18S rRNA gene sequence.

Indexed as

AspergillusBiological ProductsCluster AnalysisDNA, FungalDNA, RibosomalEgyptIndian OceanMolecular StructurePhylogenyRNA, Ribosomal, 18SSeawaterSequence Analysis, DNASpectrum AnalysisBiological ProductsDNA, FungalDNA, RibosomalRNA, Ribosomal, 18S

Identifiers

PMID31289369

DOI10.1038/s41429-019-0207-7

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