ArticleScientific reports2019
Unveiling the presence of biosynthetic pathways for bioactive compounds in the Thalassiosira rotula transcriptome.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- Coding and non-coding RNA sequencing during Thalassiosira gravida resting cell formation.Scientific data · 2026Article
- Some Bioactive Natural Products from Diatoms: Structures, Biosyntheses, Biological Roles, and Properties: 2015-2025.Marine drugs · 2026Review
- Influence of Nitrate and Light on Fucoxanthin Content and Key Gene Expression in the Marine DiatomPlants (Basel, Switzerland) · 2025Article
- Ro(a)d to New Functional Materials: Sustainable Isolation of High-Aspect-Ratio β-Chitin Microrods from Marine Algae.Bioengineering (Basel, Switzerland) · 2025Article
- High-quality genome assembly and annotation of Thalassiosira rotula (synonym of Thalassiosira gravida).Scientific data · 2025Article
- Marine Phytoplankton Bioactive Lipids and Their Perspectives in Clinical Inflammation.Marine drugs · 2025Review
- Diatom-Bacteria Interactions in the Marine Environment: Complexity, Heterogeneity, and Potential for Biotechnological Applications.Microorganisms · 2023Review
- The Clinical Promise of Microalgae in Rheumatoid Arthritis: From Natural Compounds to Recombinant Therapeutics.Marine drugs · 2023Review
- Lipid Profile, Antioxidant and Antihypertensive Activity, and Computational Molecular Docking of Diatom Fatty Acids as ACE Inhibitors.Antioxidants (Basel, Switzerland) · 2022Article
- Three Novel Bacteria Associated with Two Centric Diatom Species from the Mediterranean Sea,International journal of molecular sciences · 2021Article
- Full-Length Transcriptome ofMarine drugs · 2021Article
- Promising Activities of Marine Natural Products against Hematopoietic Malignancies.Biomedicines · 2021Review
- Chemical Defense in Marine Organisms.Marine drugs · 2020Article
- In Silico Identification of Type III PKS Chalcone and Stilbene Synthase Homologs in Marine Photosynthetic Organisms.Biology · 2020Article
- The Biotechnological Potential of the Marine DiatomMarine drugs · 2020Article
- Monogalactosyldiacylglycerol and Sulfolipid Synthesis in Microalgae.Marine drugs · 2020Article
- De novo transcriptome of the diatom Cylindrotheca closterium identifies genes involved in the metabolism of anti-inflammatory compounds.Scientific reports · 2020Article
- Identification of Prostaglandin Pathway in Dinoflagellates by Transcriptome Data Mining.Marine drugs · 2020Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diatoms are phytoplankton eukaryotic microalgae that are widely distributed in the world's oceans and are responsible for 20-25% of total carbon fixation on the planet. Using transcriptome sequencing here we show for the first time that the ubiquitous diatom Thalassiosira rotula expresses biosynthetic pathways that potentially lead to the synthesis of interesting secondary metabolites with pharmaceutical applications such as polyketides, prostaglandins and secologanin. We also show that these pathways are differentially expressed in conditions of silica depletion in comparison with standard growth conditions.
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