Evidence map›Paper›PMID 31289320›Full record

ArticleScientific reports2019

MIG1 as a positive regulator for the histidine biosynthesis pathway and as a global regulator in thermotolerant yeast Kluyveromyces marxianus.

Mochamad Nurcholis, Masayuki Murata, Savitree Limtong, Tomoyuki Kosaka, Mamoru Yamada

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Mochamad NurcholisGraduate School of Medicine, Yamaguchi University, Ube, 755-8505, Japan.
Masayuki MurataGraduate School of Science and Technology for Innovation, Yamaguchi University, Yamaguchi, 753-8515, Japan.
Savitree LimtongDepartment of Microbiology, Faculty of Science, Kasetsart University, Bangkok, 10900, Thailand.
Tomoyuki KosakaGraduate School of Science and Technology for Innovation, Yamaguchi University, Yamaguchi, 753-8515, Japan.
Mamoru YamadaGraduate School of Medicine, Yamaguchi University, Ube, 755-8505, Japan. m-yamada@yamaguchi-u.ac.jp.
Yamaguchi University · JPKasetsart University · THUniversity of Brawijaya · ID

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Kmmig1 as a disrupted mutant of MIG1 encoding a regulator for glucose repression in Kluyveromyces marxianus exhibits a histidine-auxotrophic phenotype. Genome-wide expression analysis revealed that only HIS4 in seven HIS genes for histidine biosynthesis was down-regulated in Kmmig1. Consistently, introduction of HIS4 into Kmmig1 suppressed the requirement of histidine. Considering the fact that His4 catalyzes four of ten steps in histidine biosynthesis, K. marxianus has evolved a novel and effective regulation mechanism via Mig1 for the control of histidine biosynthesis. Moreover, RNA-Seq analysis revealed that there were more than 1,000 differentially expressed genes in Kmmig1, suggesting that Mig1 is directly or indirectly involved in the regulation of their expression as a global regulator.

Indexed as

Biosynthetic PathwaysGene Expression Regulation, FungalThermotoleranceHistidineKluyveromycesRepressor ProteinsSaccharomyces cerevisiae ProteinsHistidineMIG1 protein, S cerevisiaeRepressor ProteinsSaccharomyces cerevisiae Proteins

Identifiers

PMID31289320
PMCPMC6617469
OpenAlexW2958244265

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.