ArticleProceedings of the National Academy of Sciences of the United States of America2019
YIPF6 controls sorting of FGF21 into COPII vesicles and promotes obesity.
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22citing papers in PubMed
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Who cites it
22 citing papers in PubMed, 51 citations in OpenAlex.
- Empagliflozin in the Absence of Diabetes: A Systematic Review of Its Anthropometric and Metabolic Effects in Humans and Animals.International journal of endocrinology · 2026Article
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- Selection signature analysis in chickens divergently selected for growth rate reveals novel candidate genes regulating fat deposition.BMC genomics · 2025Article
- Prominent fibroblast growth factor 21 with less abundant tumor-associated macrophages in hepatic mass of the conditional mgmt-deleted mice using LysM-Cre system.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025Article
- Noninvasive Monitoring of Steatotic Liver Disease in Western Diet-Fed Obese Mice Using Automated Ultrasound and Shear Wave Elastography.Liver international : official journal of the International Association for the Study of the Liver · 2025Article
- [Non-classical hormones from the fibroblast growth factor family].Problemy endokrinologii · 2024Review
- Signaling through the nicotinic acetylcholine receptor in the liver protects against the development of metabolic dysfunction-associated steatohepatitis.PLoS biology · 2024Article
- Fibroblast growth factor 21: An emerging pleiotropic regulator of lipid metabolism and the metabolic network.Genes & diseases · 2024Review
- Effects of Empagliflozin-Induced Glycosuria on Weight Gain, Food Intake and Metabolic Indicators in Mice Fed a High-Fat Diet.Endocrinology, diabetes & metabolism · 2024Article
- Cadherin-responsive hydrogel combined with dental pulp stem cells and fibroblast growth factor 21 promotes diabetic scald repair via regulating epithelial-mesenchymal transition and necroptosis.Materials today. Bio · 2024Article
- Alcohol drinking alters oral microbiota to modulate the progression of alcohol-related liver disease.iScience · 2023Article
- Trans-Golgi protein TVP23B regulates host-microbe interactions via Paneth cell homeostasis and Goblet cell glycosylation.Nature communications · 2023Article
- Pancreatic alpha cell glucagon-liver FGF21 axis regulates beta cell regeneration in a mouse model of type 2 diabetes.Diabetologia · 2023Article
- Fecal virome transplantation is sufficient to alter fecal microbiota and drive lean and obese body phenotypes in mice.bioRxiv : the preprint server for biology · 2023Article
- Association between iron metabolism and non-alcoholic fatty liver disease: results from the National Health and Nutrition Examination Survey (NHANES 2017-2018) and a controlled animal study.Nutrition & metabolism · 2022Article
- Hepatic FGF21: Its Emerging Role in Inter-Organ Crosstalk and Cancers.International journal of biological sciences · 2022Review
- Integrated bioinformatics analysis reveals novel key biomarkers and potential candidate small molecule drugs in gestational diabetes mellitus.Bioscience reports · 2021Article
- Changes in hepatic triglyceride content with the activation of ER stress and increased FGF21 secretion during pregnancy.Nutrition & metabolism · 2021Article
- Glucagon's Metabolic Action in Health and Disease.Comprehensive Physiology · 2021Article
- Metabolic Messengers: FGF21.Nature metabolism · 2021Review
Corrections and comments
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Authors and funding
20 authors at 5 institutions in 2 countries.
Lirui WangSchool of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, 211198 Nanjing, Jiang Su, China; wanglirui@cpu.edu.cn bruce.beutler@UTSouthwestern.edu beschnabl@ucsd.edu.
Magdalena MazagovaDepartment of Medicine, University of California San Diego, La Jolla, CA 92093.
Chuyue PanSchool of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, 211198 Nanjing, Jiang Su, China.
Song YangDepartment of Hepatology, Beijing Ditan Hospital, Capital Medical University, Chaoyang District, 100015 Beijing, China.
Katharina BrandlSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA 92093.
Jun LiuSchool of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, 211198 Nanjing, Jiang Su, China.
Shannon M ReillyDepartment of Medicine, University of California San Diego, La Jolla, CA 92093.
Yanhan WangDepartment of Medicine, University of California San Diego, La Jolla, CA 92093.
Zhaorui MiaoSchool of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, 211198 Nanjing, Jiang Su, China.
Rohit LoombaDepartment of Medicine, University of California San Diego, La Jolla, CA 92093.
Na LuSchool of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, 211198 Nanjing, Jiang Su, China.
Qinglong GuoSchool of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, 211198 Nanjing, Jiang Su, China.
Jihua LiuSchool of Traditional Chinese Pharmacy, China Pharmaceutical University, 211198 Nanjing, Jiang Su, China.
Ruth T YuGene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037.
Michael DownesGene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037.
Ronald M EvansGene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037.
David A BrennerDepartment of Medicine, University of California San Diego, La Jolla, CA 92093.
Alan R SaltielDepartment of Medicine, University of California San Diego, La Jolla, CA 92093.
Bruce BeutlerCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390 wanglirui@cpu.edu.cn bruce.beutler@UTSouthwestern.edu beschnabl@ucsd.edu.ORCID 0000-0002-3639-246X
Bernd SchnablDepartment of Medicine, University of California San Diego, La Jolla, CA 92093; wanglirui@cpu.edu.cn bruce.beutler@UTSouthwestern.edu beschnabl@ucsd.edu.
University of California San Diego · USChina Pharmaceutical University · CNSalk Institute for Biological Studies · USCapital Medical University · CNThe University of Texas Southwestern Medical Center · US
Funding
Yeast Genetics and Stress Response Genes-BiomedicalP42ES010337 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TUKEY, ROBERT H · 2000 to 2022
$69.8MTransgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PETER J TONTONOZ · 2003 to 2026
$40.4MHORMONAL REGULATION OF MAMMALIAN GENE EXPRESSIONR37DK057978 · NIDDK · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI EVANS, RONALD M · 2000 to 2019
$16.0MSan Diego Digestive Diseases Research CenterP30DK120515 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LARS ECKMANN, Bernd G. Schnabl · 2019 to 2026
$10.8MThe Role of the Exocyst Complex in Insulin Regulated Glucose TransportR01DK076906 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SALTIEL, ALAN R. · 2007 to 2019
$4.6MSpatial Regulation of Developmental Gene ExpressionR01HL105278 · NHLBI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI EVANS, RONALD M · 2011 to 2019
$4.0MThe Role of the Intestinal Mycobiome in Alcoholic Liver DiseaseR01AA024726 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Bernd G. Schnabl · 2018 to 2026
$3.9MMicrobiome and intestinal innate immune response in alcoholic liver diseaseR01AA020703 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SCHNABL, BERND G. · 2011 to 2020
$3.6MMicrobiome and Intestinal Innate Immune Response in Alcoholic Liver DiseaseR37AA020703 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Bernd G. Schnabl · 2021 to 2026
$2.5MMicrobiome as Therapeutic Target in Alcoholic HepatitisU01AA021856 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BRENNER, DAVID A., SCHNABL, BERND G. · 2013 to 2017
$2.1MThe Role of the Intestinal Mycobiome in Alcoholic Liver DiseaseU01AA024726 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SCHNABL, BERND G. · 2017 to 2017
$353kBLRD VA I01 BX002213NHLBI NIH HHS R01 HL105278NIAAA NIH HHS R01 AA020703NIAAA NIH HHS R01 AA024726NIAAA NIH HHS R37 AA020703NIAAA NIH HHS U01 AA021856NIAAA NIH HHS U01 AA024726NIDDK NIH HHS P30 DK063491NIDDK NIH HHS P30 DK120515NIDDK NIH HHS R01 DK076906NIDDK NIH HHS R37 DK057978NIEHS NIH HHS P42 ES010337
Abstract
Fibroblast growth factor 21 (FGF21) is an endocrine hormone that regulates glucose, lipid, and energy homeostasis. While gene expression of FGF21 is regulated by the nuclear hormone receptor peroxisome proliferator-activated receptor alpha in the fasted state, little is known about the regulation of trafficking and secretion of FGF21. We show that mice with a mutation in the Yip1 domain family, member 6 gene (
Indexed as
AnimalsBody TemperatureCOP-Coated VesiclesDiet, High-FatEndoplasmic ReticulumEnergy MetabolismFibroblast Growth FactorsGene Expression RegulationHepatocytesHumansLipolysisLiverMembrane ProteinsMetabolic SyndromeMiceMice, Knockoutfibroblast growth factor 21Fibroblast Growth FactorsMembrane ProteinsVesicular Transport ProteinsYIPF6 protein, humanYipf6 protein, mouseCOPII vesiclesFGF21obesitysorting receptorYIPF6
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