ArticleScience signaling2019
The L-type amino acid transporter LAT1 inhibits osteoclastogenesis and maintains bone homeostasis through the mTORC1 pathway.
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In one paragraph
Article in Science signaling, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 16% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Low Circulating Valine Associate With High Risk of Hip Fractures.The Journal of clinical endocrinology and metabolism · 2023Pooled it
- Amino Acid Metabolism in Health and Disease.MedComm · 2026Review
- Spectrum and functions of ion channels and transporters in osteoclasts.Bone research · 2026Review
- The amino acid transporter LAT1 coordinates proper motor function at the perinatal stage.Cell death & disease · 2026Article
- Nutrients and Metabolites as Signalling Molecules in Osteoclasts.Current osteoporosis reports · 2026Review
- Branched‑chain amino acid metabolism and bone metabolism: Implications for osteoporosis pathogenesis and therapeutic strategies (Review).International journal of molecular medicine · 2026Review
- System L Amino Acid Transporter LAT1 is required for Mouse Intestinal Epithelial Homeostasis.International journal of biological sciences · 2026Article
- Canagliflozin-Induced Adaptive Metabolism in Bone.Diabetes · 2025Article
- GRAMMAR-Lambda Delivers Efficient Understanding of the Genetic Basis for Head Size in Catfish.Biology · 2025Article
- Branched-Chain Amino Acid Metabolic Reprogramming and Cancer: Molecular Mechanisms, Immune Regulation, and Precision Targeting.Oncology research · 2025Review
- Association Between Dietary Tryptophan Intake and Bone Health: A Cross-Sectional Study.Calcified tissue international · 2024Article
- Functional characterization of theHeliyon · 2024Article
- Metabolic regulation of skeletal cell fate and function.Nature reviews. Endocrinology · 2024Review
- Trophoblast-specific overexpression of the LAT1 increases transplacental transport of essential amino acids and fetal growth in mice.PNAS nexus · 2024Article
- Unraveling the intricacies of osteoclast differentiation and maturation: insight into novel therapeutic strategies for bone-destructive diseases.Experimental & molecular medicine · 2024Review
- Amino acid transporter SLC7A5 regulates cell proliferation and secretary cell differentiation and distribution in the mouse intestine.International journal of biological sciences · 2024Article
- Unraveling the role of serum metabolites in the relationship between plant-based diets and bone health in community-dwelling older adults.Current research in food science · 2024Article
- Novel Insights into Osteoclast Energy Metabolism.Current osteoporosis reports · 2023Review
- The effects of BPA-BNCT on normal bone: determination of the CBE value in mice‡.Journal of radiation research · 2023Article
- l-Type amino acid transporter 1 in hypothalamic neurons in mice maintains energy and bone homeostasis.JCI insight · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 5 institutions in 3 countries.
Kakeru OzakiLaboratory of Molecular Pharmacology, Division of Pharmaceutical Sciences, Kanazawa University Graduate School, Kanazawa, Ishikawa 920-1192, Japan.
Takanori YamadaLaboratory of Molecular Pharmacology, Division of Pharmaceutical Sciences, Kanazawa University Graduate School, Kanazawa, Ishikawa 920-1192, Japan.ORCID 0000-0002-8919-6075
Tetsuhiro HorieLaboratory of Molecular Pharmacology, Division of Pharmaceutical Sciences, Kanazawa University Graduate School, Kanazawa, Ishikawa 920-1192, Japan.ORCID 0000-0002-2095-9425
Atsushi IshizakiLaboratory of Clinical Analytical Sciences, Division of Pharmaceutical Sciences, Kanazawa University Graduate School, Kanazawa, Ishikawa 920-1192, Japan.ORCID 0000-0001-8750-1331
Manami HiraiwaLaboratory of Molecular Pharmacology, Division of Pharmaceutical Sciences, Kanazawa University Graduate School, Kanazawa, Ishikawa 920-1192, Japan.
Takashi IezakiLaboratory of Molecular Pharmacology, Division of Pharmaceutical Sciences, Kanazawa University Graduate School, Kanazawa, Ishikawa 920-1192, Japan.ORCID 0000-0003-3037-5156
Gyujin ParkLaboratory of Molecular Pharmacology, Division of Pharmaceutical Sciences, Kanazawa University Graduate School, Kanazawa, Ishikawa 920-1192, Japan.
Kazuya FukasawaLaboratory of Molecular Pharmacology, Division of Pharmaceutical Sciences, Kanazawa University Graduate School, Kanazawa, Ishikawa 920-1192, Japan.
Hikari KamadaLaboratory of Molecular Pharmacology, Division of Pharmaceutical Sciences, Kanazawa University Graduate School, Kanazawa, Ishikawa 920-1192, Japan.
Kazuya TokumuraLaboratory of Molecular Pharmacology, Division of Pharmaceutical Sciences, Kanazawa University Graduate School, Kanazawa, Ishikawa 920-1192, Japan.
Mei MotonoLaboratory of Molecular Pharmacology, Division of Pharmaceutical Sciences, Kanazawa University Graduate School, Kanazawa, Ishikawa 920-1192, Japan.
Katsuyuki KanedaLaboratory of Molecular Pharmacology, Division of Pharmaceutical Sciences, Kanazawa University Graduate School, Kanazawa, Ishikawa 920-1192, Japan.
Kazuma OgawaLaboratory of Clinical Analytical Sciences, Division of Pharmaceutical Sciences, Kanazawa University Graduate School, Kanazawa, Ishikawa 920-1192, Japan.
Hiroki OchiDepartment of Physiology and Cell Biology, Tokyo Medical and Dental University, Graduate School, Tokyo 113-8510, Japan.
Shingo SatoDepartment of Physiology and Cell Biology, Tokyo Medical and Dental University, Graduate School, Tokyo 113-8510, Japan.ORCID 0000-0002-6227-5910
Yasuhiro KobayashiInstitute for Oral Science, Matsumoto Dental University, Shiojiri, Nagano 399-0781, Japan.ORCID 0000-0002-0903-3226
Yun-Bo ShiSection on Molecular Morphogenesis, Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, MD 20892, USA.
Peter M TaylorDivision of Cell Signalling and Immunology, School of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK.ORCID 0000-0003-0572-4502
Eiichi HinoiLaboratory of Molecular Pharmacology, Division of Pharmaceutical Sciences, Kanazawa University Graduate School, Kanazawa, Ishikawa 920-1192, Japan. hinoi@p.kanazawa-u.ac.jp.ORCID 0000-0002-1298-8293
Kanazawa University · JPTokyo Medical and Dental University · JPEunice Kennedy Shriver National Institute of Child Health and Human Development · USMatsumoto Dental University · JPUniversity of Dundee · GB
Funding
Regulation of stem cell development during tissue remodelingZIAHD008858 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI SHI, YUN-BO · 2009 to 2025
$15.2MIntramural NIH HHS ZIA HD008858
Abstract
L-type amino acid transporter 1 (LAT1), which is encoded by
Indexed as
Amino Acid Transport System y+LAnimalsBone and BonesBone ResorptionCells, CulturedFemaleHomeostasisMechanistic Target of Rapamycin Complex 1Mice, Inbred C57BLMice, KnockoutMice, TransgenicNFATC Transcription FactorsNF-kappa BOsteoclastsOsteogenesisOvariectomyAmino Acid Transport System y+LMechanistic Target of Rapamycin Complex 1NFATC Transcription FactorsNF-kappa BProto-Oncogene Proteins c-aktSlc7a7 protein, mouse
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.