Evidence map›Paper›PMID 31289199›Full record

ArticleHaematologica2020

Impact of clinical, cytogenetic, and molecular profiles on long-term survival after transplantation in patients with chronic myelomonocytic leukemia.

Janghee Woo, Dae Ro Choi, Barry E Storer, Cecilia Yeung, Anna B Halpern, Rachel B Salit, Mohamed L Sorror, David W Woolston, Tim Monahan, Bart L Scott and 1 more

Open access · goldAbstract read
In one paragraph

Article in Haematologica, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 33 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Observational
  8. Article
  9. Review
  10. Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. Review
  16. Article
  17. Genomics of myelodysplastic syndrome/myeloproliferative neoplasm overlap syndromes.Hematology. American Society of Hematology. Education Program · 2020
    Review
  18. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Janghee WooFred Hutchinson Cancer Research Center.
Dae Ro ChoiFred Hutchinson Cancer Research Center.
Barry E StorerFred Hutchinson Cancer Research Center.
Cecilia YeungFred Hutchinson Cancer Research Center.
Anna B HalpernFred Hutchinson Cancer Research Center.
Rachel B SalitFred Hutchinson Cancer Research Center.
Mohamed L SorrorFred Hutchinson Cancer Research Center.
David W WoolstonFred Hutchinson Cancer Research Center.
Tim MonahanFred Hutchinson Cancer Research Center.
Bart L ScottFred Hutchinson Cancer Research Center.
H Joachim DeegFred Hutchinson Cancer Research Center jdeeg@fredhutch.org.
Fred Hutch Cancer Center · USUniversity of Washington · US

Funding

Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Eric Collisson · 1985 to 2026
$296.4M
VIRUS-MEDIATED MYELOSUPPRESSIONP01CA018029 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Evan Newell · 1985 to 2026
$128.4M
CAREER DEVELOPMENT IN PEDIATRIC AND MEDICAL ONCOLOGYK12CA076930 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI DAVIDSON, NANCY ELLEN, MESHINCHI, SOHEIL · 1997 to 2025
$13.1M
NCI NIH HHS K12 CA076930NCI NIH HHS P01 CA018029NCI NIH HHS P30 CA015704
6 · The paper itself

Abstract

Chronic myelomonocytic leukemia (CMML) is a heterogeneous group of clonal hematopoietic malignancies with variable clinical and molecular features. We analyzed long-term results of allogeneic hematopoietic cell transplantation in patients with CMML and determined clinical and molecular risk factors associated with outcomes. Data from 129 patients, aged 7-74 (median 55) years, at various stages of the disease and transplanted from related or unrelated donors were analyzed. Using a panel of 75 genes somatic mutations present before hematopoietic cell transplantation were identified In 52 patients. The progression-free survival rate at 10 years was 29%. The major cause of death was relapse (32%), which was significantly associated with adverse cytogenetics (hazard ratio, 3.77;

Indexed as

Hematopoietic Stem Cell TransplantationLeukemia, Myelomonocytic, ChronicLeukemia, Myelomonocytic, JuvenileAdolescentAdultAgedChildCytogenetic AnalysisHumansMiddle AgedPrognosisTreatment OutcomeYoung Adult

Identifiers

PMID31289199
PMCPMC7049334
OpenAlexW2961368521

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.