Evidence map›Paper›PMID 31289190›Full record

ArticlemBio2019

Targeting Mannitol Metabolism as an Alternative Antimicrobial Strategy Based on the Structure-Function Study of Mannitol-1-Phosphate Dehydrogenase in Staphylococcus aureus.

Thanh Nguyen, Truc Kim, Hai Minh Ta, Won Sik Yeo, Jongkeun Choi, Pushpak Mizar, Seung Seo Lee, Taeok Bae, Akhilesh Kumar Chaurasia, Kyeong Kyu Kim

Open access · goldAbstract read
In one paragraph

Article in mBio, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 54 citations in OpenAlex.

  1. Article
  2. Article
  3. Journal of fungi (Basel, Switzerland) · 2025
    Article
  4. Article
  5. Article
  6. Genomic and metabolic characterization ofApplied and environmental microbiology · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. ISME communications · 2024
    Article
  11. Article
  12. Integrated genomic and functional analyses of human skin-associatedProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  13. Comparative genomic analysis ofApplied and environmental microbiology · 2023
    Article
  14. Article
  15. Article
  16. Article
  17. Unidirectional mannitol synthesis ofProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  18. Frontiers in microbiology · 2022
    Article
  19. Article
  20. Selected Metabolites Profiling ofFrontiers in microbiology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Thanh NguyenDepartment of Molecular Cell Biology, Institute for Antimicrobial Research and Therapeutics, Sungkyunkwan University School of Medicine, Suwon, South Korea.
Truc KimDepartment of Molecular Cell Biology, Institute for Antimicrobial Research and Therapeutics, Sungkyunkwan University School of Medicine, Suwon, South Korea.
Hai Minh TaDepartment of Molecular Cell Biology, Institute for Antimicrobial Research and Therapeutics, Sungkyunkwan University School of Medicine, Suwon, South Korea.
Won Sik YeoDepartment of Microbiology and Immunology, Indiana University School of Medicine Northwest, Gary, Indiana, USA.
Jongkeun ChoiDepartment of Chemical Engineering, Chungwoon University, Incheon, South Korea.
Pushpak MizarSchool of Chemistry, University of Southampton, Southampton, United Kingdom.
Seung Seo LeeSchool of Chemistry, University of Southampton, Southampton, United Kingdom.ORCID 0000-0002-8598-3303
Taeok BaeDepartment of Microbiology and Immunology, Indiana University School of Medicine Northwest, Gary, Indiana, USA.ORCID 0000-0002-0576-2851
Akhilesh Kumar ChaurasiaDepartment of Molecular Cell Biology, Institute for Antimicrobial Research and Therapeutics, Sungkyunkwan University School of Medicine, Suwon, South Korea chaurasia@skku.edu kyeongkyu@skku.edu.
Kyeong Kyu KimDepartment of Molecular Cell Biology, Institute for Antimicrobial Research and Therapeutics, Sungkyunkwan University School of Medicine, Suwon, South Korea chaurasia@skku.edu kyeongkyu@skku.edu.
Sungkyunkwan University · KRIndiana University Northwest · USUniversity of Southampton · GBChungwoon University · KRSamsung Medical Center · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mannitol-1-phosphate dehydrogenase (M1PDH) is a key enzyme in

Indexed as

AnimalsAnti-Bacterial AgentsFemaleMacrophagesMaleMannitolMethicillin-Resistant Staphylococcus aureusMiceMice, Inbred C57BLMolecular Docking SimulationMutationRAW 264.7 CellsStaphylococcal InfectionsSugar Alcohol DehydrogenasesVirulenceAnti-Bacterial AgentsMannitolmannitol-1-phosphate dehydrogenaseSugar Alcohol Dehydrogenasesantibiotic targetantimicrobial resistancecrystal structureinhibitormannitolmannitol-1-phosphate dehydrogenaseStaphylococcus aureusvirulence

Identifiers

PMID31289190
PMCPMC6623548
OpenAlexW2961167620

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.