Evidence map›Paper›PMID 31289182›Full record

ArticlemBio2019

Bactericidal Disruption of Magnesium Metallostasis in Mycobacterium tuberculosis Is Counteracted by Mutations in the Metal Ion Transporter CorA.

Landys Lopez Quezada, Sandra Silve, Mark Kelinske, Amir Liba, Constantino Diaz Gonzalez, Martin Kotev, Laurent Goullieux, Stephanie Sans, Christine Roubert, Sophie Lagrange and 14 more

Open access · goldAbstract read
In one paragraph

Article in mBio, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Molecular Dynamics and Other HPC Simulations for Drug Discovery.Methods in molecular biology (Clifton, N.J.) · 2024
    Article
  2. Preparation and Characterization of Calcium-IncorporatedEvidence-based complementary and alternative medicine : eCAM · 2022
    Article
  3. Fine tuning for success in structure-based virtual screening.Journal of computer-aided molecular design · 2021
    Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 3 institutions in 1 country.

Landys Lopez QuezadaDepartment of Microbiology and Immunology, Weill Cornell Medicine, New York, New York, USA.
Sandra SilveEvotec Infectious Diseases (Lyon), Marcy l'Etoile, France.
Mark KelinskeAgilent Technologies, Inc., Wilmington, Delaware, USA.
Amir LibaAgilent Technologies, Inc., Wilmington, Delaware, USA.
Constantino Diaz GonzalezEvotec Research Informatics (Toulouse), Toulouse, France.
Martin KotevEvotec Research Informatics (Toulouse), Toulouse, France.
Laurent GoullieuxEvotec Infectious Diseases (Lyon), Marcy l'Etoile, France.
Stephanie SansEvotec Infectious Diseases (Lyon), Marcy l'Etoile, France.
Christine RoubertEvotec Infectious Diseases (Lyon), Marcy l'Etoile, France.
Sophie LagrangeEvotec Infectious Diseases (Lyon), Marcy l'Etoile, France.
Eric BacquéEvotec Infectious Diseases (Lyon), Marcy l'Etoile, France.
Cedric CouturierEvotec Infectious Diseases (Lyon), Marcy l'Etoile, France.
Alain PelletEvotec Infectious Diseases (Lyon), Marcy l'Etoile, France.
Isabelle BlancEvotec Infectious Diseases (Lyon), Marcy l'Etoile, France.
Marlène FerronEvotec Infectious Diseases (Lyon), Marcy l'Etoile, France.
Fabrice DebuEvotec Infectious Diseases (Lyon), Marcy l'Etoile, France.
Kelin LiDivision of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Jeffrey AubéDivision of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID 0000-0003-1049-5767
Julia RobertsDepartment of Microbiology and Immunology, Weill Cornell Medicine, New York, New York, USA.
David LittleDepartment of Microbiology and Immunology, Weill Cornell Medicine, New York, New York, USA.
Yan LingDepartment of Microbiology and Immunology, Weill Cornell Medicine, New York, New York, USA.
Jun ZhangDepartment of Microbiology and Immunology, Weill Cornell Medicine, New York, New York, USA.
Ben GoldDepartment of Microbiology and Immunology, Weill Cornell Medicine, New York, New York, USA.
Carl NathanDepartment of Microbiology and Immunology, Weill Cornell Medicine, New York, New York, USA cnathan@med.cornell.edu.ORCID 0000-0002-7744-8896
Cornell University · USAgilent Technologies (United States) · USUniversity of North Carolina at Chapel Hill · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A defining characteristic of treating tuberculosis is the need for prolonged administration of multiple drugs. This may be due in part to subpopulations of slowly replicating or nonreplicating

Indexed as

Antitubercular AgentsCation Transport ProteinsDNA ReplicationHomeostasisMagnesiumMutationMycobacterium tuberculosisAntitubercular AgentsCation Transport ProteinsMagnesiumCorAmagnesiummycobacteriumtuberculosis

Identifiers

PMID31289182
PMCPMC6747715
OpenAlexW2961135345

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.