SynthesisAnnals of the rheumatic diseases2019
Genome-wide association study revealed novel loci which aggravate asymptomatic hyperuricaemia into gout.
Open access · hybridAbstract readMeta-Analysis
In one paragraph
Synthesis in Annals of the rheumatic diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 3 of them syntheses that pooled it.
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50citing papers in PubMed, 3 pooled it
10.9field-weighted citation impact, top 1% of its field
What it found
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Who cites it
50 citing papers in PubMed, 3 syntheses or guidelines pooled it, 103 citations in OpenAlex.
- Both variants of A1CF and BAZ1B genes are associated with gout susceptibility: a replication study and meta-analysis in a Japanese population.Human cell · 2021Pooled it
- The association between genetic polymorphisms in ABCG2 and SLC2A9 and urate: an updated systematic review and meta-analysis.BMC medical genetics · 2020Pooled it
- Subtype-specific gout susceptibility loci and enrichment of selection pressure onAnnals of the rheumatic diseases · 2020Pooled it
- Effects of ABCG2 dysfunction on hyperuricemia progression in premenopausal and postmenopausal women.Human cell · 2026Article
- Using Multi-Omics Methods to Understand Gouty Arthritis.Current rheumatology reviews · 2026Review
- Colocalization analysis reveals shared genetic loci contributing to gout and metabolite levels.Gout, urate, and crystal deposition disease · 2025Article
- ALDH2 Ameliorates Acute Gouty Arthritis Through Inhibiting NLRP3 Inflammasome and Pyroptosis by Nrf2/ROS Pathway.Journal of inflammation research · 2025Article
- Gout-associated SNP at the IL1RN-IL1F10 region is associated with altered cytokine production in PBMCs of patients with gout and controls.Arthritis research & therapy · 2024Article
- NUMB dysfunction defines a novel mechanism underlying hyperuricemia and gout.Cell discovery · 2024Article
- The pathogenesis of gout: molecular insights from genetic, epigenomic and transcriptomic studies.Nature reviews. Rheumatology · 2024Review
- Plasma and Urinary Metabolomic Analysis of Gout and Asymptomatic Hyperuricemia and Profiling of Potential Biomarkers: A Pilot Study.Biomedicines · 2024Article
- Correlation analysis of serum TLR4 protein levels and TLR4 gene polymorphisms in gouty arthritis patients.PloS one · 2024Article
- The Evolving Landscape of Gout in the Female: A Narrative Review.Gout, urate, and crystal deposition disease · 2023Article
- Dysuricemia.Biomedicines · 2023Review
- Genetic and epidemiological analyses of infection load and its relationship with psychiatric disorders.Epidemiology and infection · 2023Article
- Enrichment analysis and chromosomal distribution of gout susceptible loci identified by genome-wide association studies.EXCLI journal · 2023Article
- Systematic Review of the Role of Alpha-Protein Kinase 1 in Cancer and Cancer-Related Inflammatory Diseases.Cancers · 2022Review
- Meta-analysis of HNF1A-MODY3 variants among human population.Journal of diabetes and metabolic disorders · 2022Review
- Differential gene expression of ABCG2, SLC22A12, IL-1β, and ALPK1 in peripheral blood leukocytes of primary gout patients with hyperuricemia and their comorbidities: a case-control study.European journal of medical research · 2022Article
- Weak Association Between Genetic Markers of Hyperuricemia and Cardiorenal Outcomes: Insights From the STANISLAS Study Cohort With a 20-Year Follow-Up.Journal of the American Heart Association · 2022Article
Corrections and comments
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Authors and funding
49 authors at 20 institutions in 3 countries.
Yusuke Kawamura *Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, Saitama, Japan.
Hirofumi Nakaoka *Division of Human Genetics, Department of Integrated Genetics, National Institute of Genetics, Mishima, Shizuoka, Japan.
Akiyoshi Nakayama *Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, Saitama, Japan.
Yukinori Okada *Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.ORCID 0000-0002-0311-8472
Ken Yamamoto *Department of Medical Biochemistry, Kurume University School of Medicine, Kurume, Fukuoka, Japan.
Toshihide HigashinoDepartment of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, Saitama, Japan.
Masayuki SakiyamaDepartment of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, Saitama, Japan.
Toru ShimizuMidorigaoka Hospital, Takatsuki, Osaka, Japan.
Hiroshi OoyamaRyougoku East Gate Clinic, Tokyo, Japan.
Keiko OoyamaRyougoku East Gate Clinic, Tokyo, Japan.
Mitsuo NagaseNagase Clinic, Tokyo, Japan.
Yuji HidakaAkasaka Central Clinic, Tokyo, Japan.
Yuko ShirahamaDepartment of Medical Biochemistry, Kurume University School of Medicine, Kurume, Fukuoka, Japan.
Kazuyoshi HosomichiDepartment of Bioinformatics and Genomics, Graduate School of Advanced Preventive Medical Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan.
Yuichiro NishidaDepartment of Preventive Medicine, Faculty of Medicine, Saga University, Saga, Japan.
Ippei ShimoshikiryoDepartment of International Island and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
Asahi HishidaDepartment of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.
Sakurako Katsuura-KamanoDepartment of Preventive Medicine, Institute of Health Biosciences, the University of Tokushima Graduate School, Tokushima, Japan.
Seiko ShimizuDepartment of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, Saitama, Japan.
Makoto KawaguchiDepartment of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, Saitama, Japan.
Hirokazu UemuraDepartment of Preventive Medicine, Institute of Health Biosciences, the University of Tokushima Graduate School, Tokushima, Japan.
Rie IbusukiDepartment of International Island and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
Megumi HaraDepartment of Preventive Medicine, Faculty of Medicine, Saga University, Saga, Japan.
Mariko NaitoDepartment of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.
Mikiya TakaoDepartment of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, Saitama, Japan.
Mayuko NakajimaDepartment of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, Saitama, Japan.
Satoko IwasawaDepartment of Preventive Medicine and Public Health, National Defense Medical College, Tokorozawa, Saitama, Japan.
Hiroshi NakashimaDepartment of Preventive Medicine and Public Health, National Defense Medical College, Tokorozawa, Saitama, Japan.
Keizo OhnakaDepartment of Geriatric Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Takahiro NakamuraLaboratory for Mathematics, National Defense Medical College, Tokorozawa, Saitama, Japan.
Blanka StiburkovaInstitute of Rheumatology, Prague, Czech Republic.
Tony R MerrimanDepartment of Biochemisty, University of Otago, Dunedin, New Zealand.
Masahiro NakatochiData Science Division, Data Coordinating Center, Department of Advanced Medicine, Nagoya University Hospital, Nagoya, Aichi, Japan.
Sahoko IchiharaDepartment of Environmental and Preventive Medicine, Jichi Medical University School of Medicine, Shimotsuke, Tochigi, Japan.
Mitsuhiro YokotaDepartment of Genome Science, School of Dentistry, Aichi Gakuin University, Nagoya, Aichi, Japan.
Tappei TakadaDepartment of Pharmacy, the University of Tokyo Hospital, Tokyo, Japan.
Tatsuya SaitohLaboratory of Bioresponse Regulation, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, Japan.
Yoichiro KamataniLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, Japan.
Atsushi TakahashiLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, Japan.
Kokichi ArisawaDepartment of Preventive Medicine, Institute of Health Biosciences, the University of Tokushima Graduate School, Tokushima, Japan.
Toshiro TakezakiDepartment of International Island and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
Keitaro TanakaDepartment of Preventive Medicine, Faculty of Medicine, Saga University, Saga, Japan.
Kenji WakaiDepartment of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.
Michiaki KuboRIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, Japan.
Tatsuo HosoyaDivision of Kidney and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Minato-ku, Tokyo, Japan.
Kimiyoshi IchidaDivision of Kidney and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Minato-ku, Tokyo, Japan.
Ituro InoueDivision of Human Genetics, Department of Integrated Genetics, National Institute of Genetics, Mishima, Shizuoka, Japan.
Nariyoshi ShinomiyaDepartment of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, Saitama, Japan.
Hirotaka MatsuoDepartment of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, Saitama, Japan hmatsuo@ndmc.ac.jp.ORCID 0000-0001-5021-1613
National Defense Medical College · JPTokushima University · JPKagoshima University · JPSaga University · JPJikei University School of Medicine · JPKurume University Medical Center · JPNagoya University · JPNational Institute of Genetics · JPRIKEN Center for Integrative Medical Sciences · JPAichi Gakuin University · JPCharles University · CZHiroshima University · JPJapan Industrial Safety and Health Association · JPJichi Medical University · JPKanazawa University · JPKyoto University · JPKyushu University · JPNagase (Japan) · JPNagoya University Hospital · JPNational Cerebral and Cardiovascular Center · JP
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe first ever genome-wide association study (GWAS) of clinically defined gout cases and asymptomatic hyperuricaemia (AHUA) controls was performed to identify novel gout loci that aggravate AHUA into gout.
methodsWe carried out a GWAS of 945 clinically defined gout cases and 1003 AHUA controls followed by 2 replication studies. In total, 2860 gout cases and 3149 AHUA controls (all Japanese men) were analysed. We also compared the ORs for each locus in the present GWAS (gout vs AHUA) with those in the previous GWAS (gout vs normouricaemia).
resultsThis new approach enabled us to identify two novel gout loci (rs7927466 of
conclusionsThis meta-analysis is the first to reveal the loci associated with crystal-induced inflammation, the last step in gout development that aggravates AHUA into gout. Our findings should help to elucidate the molecular mechanisms of gout development and assist the prevention of gout attacks in high-risk AHUA individuals.
Indexed as
AdultAldehyde Dehydrogenase, MitochondrialAsymptomatic DiseasesATP Binding Cassette Transporter, Subfamily G, Member 2ContactinsGenetic LociGenome-Wide Association StudyGenotyping TechniquesGlucose Transport Proteins, FacilitativeGoutHumansHyperuricemiaMaleMicroRNAsMiddle AgedNeoplasm ProteinsABCG2 protein, humanAldehyde Dehydrogenase, MitochondrialALDH2 protein, humanATP Binding Cassette Transporter, Subfamily G, Member 2CNTN5 protein, humanContactinsGlucose Transport Proteins, FacilitativeMicroRNAsMIRN302A microRNA, humanNeoplasm ProteinsSLC2A9 protein, humanUric Acidasymptomatic hyperuricemiagenome-wide association studygoutindividually-tailored preemptive medicineuric acid
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