Evidence map›Paper›PMID 31289091›Full record

ArticleBMJ open2019

Evaluating the effectiveness and cost-effectiveness of health facility-based and community-based index-linked HIV testing strategies for children: protocol for the B-GAP study in Zimbabwe.

Chido Dziva Chikwari, Victoria Simms, Stefanie Dringus, Katharina Kranzer, Tsitsi Bandason, Arthi Vasantharoopan, Rudo Chikodzore, Edwin Sibanda, Miriam Mutseta, Karen Webb and 6 more

Open access · goldAbstract read
In one paragraph

Article in BMJ open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 2 countries.

Chido Dziva ChikwariDepartment of Clinical Research, London School of Hygiene and Tropical Medicine, London, UK.ORCID 0000-0003-1617-3603
Victoria SimmsMRC Tropical Epidemiology Group, London School of Hygiene and Tropical Medicine, London, UK.
Stefanie DringusLondon School of Hygiene and Tropical Medicine, London, UK.
Katharina KranzerBiomedical Research and Training Institute, Harare, Zimbabwe.
Tsitsi BandasonBiomedical Research and Training Institute, Harare, Zimbabwe.
Arthi VasantharoopanLondon School of Hygiene and Tropical Medicine, London, UK.
Rudo ChikodzoreMatebeleland South, Ministry of Health and Child Care, Bulawayo, Zimbabwe.
Edwin SibandaCity Health Department, Bulawayo City Council, Bulawayo, Zimbabwe.
Miriam MutsetaPopulation Services International Zimbabwe, Harare, Zimbabwe.
Karen WebbOrganization for Public Health Interventions and Development, Harare, Zimbabwe.
Barbara EngelsmannOrganization for Public Health Interventions and Development, Harare, Zimbabwe.
Gertrude NcubeMinistry of Health and Child Care Zimbabwe, Harare, Zimbabwe.
Hilda MujuruCollege of Health Sciences, University of Zimbabwe, Harare, Zimbabwe.
Tsitsi ApolloMinistry of Health and Child Care Zimbabwe, Harare, Zimbabwe.
Helen Anne WeissMRC Tropical Epidemiology Group, London School of Hygiene and Tropical Medicine, London, UK.ORCID 0000-0003-3547-7936
Rashida FerrandDepartment of Clinical Research, London School of Hygiene and Tropical Medicine, London, UK.
London School of Hygiene & Tropical Medicine · GBMinistry of Health and Child Welfare · ZWBiomedical Research and Training Institute · ZWMpilo Central Hospital · ZWUniversity of Zimbabwe · ZW

Funding

Training for Research Excellence and MeNtorship in Tuberculosis (TRENT)D43TW009539 · FIC · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI METCALFE, JOHN ZAPATA · 2013 to 2022
$2.9M
FIC NIH HHS D43 TW009539Medical Research Council MR/P011268/1Medical Research Council MR/R010161/1Wellcome TrustWellcome Trust 206316/Z/17/Z
6 · The paper itself

Abstract

introductionThe number of new paediatric infections per year has declined in sub-Saharan Africa due to prevention-of-mother-to-child HIV transmission programmes; many children and adolescents living with HIV remain undiagnosed. In this protocol paper, we describe the methodology for evaluating an index-linked HIV testing approach for children aged 2-18 years in health facility and community settings in Zimbabwe. METHODS AND ANALYSIS: Individuals attending for HIV care at selected primary healthcare clinics (PHCs) will be asked if they have any children aged 2-18 years in their households who have not been tested for HIV. Three options for HIV testing for these children will be offered: testing at the PHC; home-based testing performed by community workers; or an oral mucosal HIV test given to the caregiver to test the children at home. All eligible children will be followed-up to ascertain whether HIV testing occurred. For those who did not test, reasons will be determined, and for those who tested, the HIV test result will be recorded. The primary outcome will be uptake of HIV testing. The secondary outcomes will be preferred HIV testing method, HIV yield, prevalence and proportion of those testing positive linking to care and having an undetectable viral load at 12 months. HIV test results will be stratified by sex and age group, and factors associated with uptake of HIV testing and choice of HIV testing method will be investigated. ETHICS AND DISSEMINATION: Ethical approval for this study was granted by the Medical Research Council of Zimbabwe, the London School of Hygiene and Tropical Medicine and the Institutional Review Board of the Biomedical Research and Training Institute. Study results will be presented at national policy meetings and national and international research conferences. Results will also be published in international peer-reviewed scientific journals and disseminated to study communities at the end of study.

Indexed as

Community Health ServicesHealth Services AccessibilityMass ScreeningAdolescentChildChild, PreschoolCost-Benefit AnalysisFemaleHIV InfectionsHumansMaleZimbabweadolescentschildrencommunityindex-linked testingoral mucosal HIV test

Identifiers

PMID31289091
PMCPMC6615786
OpenAlexW2956019637

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.