ArticleBMC pregnancy and childbirth2019
Hypertensive disorders of pregnancy are associated with an inflammatory state: evidence from hematological findings and cytokine levels.
Article in BMC pregnancy and childbirth, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 49 citations in OpenAlex.
- The impact of low-dose aspirin on hemoglobin levels in pregnancy: A secondary analysis of a randomized controlled trial for prevention of hypertensive disorders of pregnancy.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026Trial
- Experiences of discrimination, paternal support, and hypertensive disorders of pregnancy (HDP) in the MIEHR study, Houston, Texas.International journal for equity in health · 2026Article
- Low-dose aspirin and anaemia risk in pregnancy: A scoping review with emphasis on low- and middle-income contexts.South African family practice : official journal of the South African Academy of Family Practice/Primary Care · 2026Article
- Association of first trimester peripheral blood count-derived immune markers with the risk of incident hypertensive disorders of pregnancy: a retrospective cohort study.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Cell-free mitochondrial DNA and microRNA-137 for early diagnosis of preeclampsia.Frontiers in cardiovascular medicine · 2026Article
- Analysis of the association between history of gestational diabetes mellitus and hypertensive disorders in a subsequent pregnancy: a retrospective cohort study.Frontiers in endocrinology · 2026Article
- Joint effects of traffic-related air pollution and hypertensive disorders of pregnancy on maternal postpartum depressive and anxiety symptoms.Journal of exposure science & environmental epidemiology · 2025Article
- An endogenous aryl hydrocarbon receptor ligand induces preeclampsia-like phenotypes in rats.The Journal of physiology · 2025Article
- Coagulation indices for predicting hypertensive pregnancy disorders.American journal of translational research · 2025Article
- Association of maternal leukocyte, monocyte, and neutrophil counts with hypertensive disorders of pregnancy: the Japan Environment and Children's Study (JECS).Scientific reports · 2024Article
- Serum Macrophage Colony-Stimulating Factor Relates to the Severity and the Pregnancy Outcomes in Hypertensive Disorders Complicating Pregnancy.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2024Article
- Prevalence of persistent hypertension following pregnancy complicated by hypertensive disorders in low- and middle-income countries: a systematic review.Frontiers in global women's health · 2024Review
- Energy-Adjusted Dietary Inflammatory Index in pregnancy and maternal cardiometabolic health: findings from the ROLO study.AJOG global reports · 2023Article
- Exploring the role of T helper subgroups and their cytokines in the development of pregnancy-induced hypertension.Frontiers in immunology · 2023Article
- Hypertensive disorders of pregnancy share common cfDNA methylation profiles.Scientific reports · 2022Article
- Cardiometabolic Pregnancy Complications in Association With Autism-Related Traits as Measured by the Social Responsiveness Scale in ECHO.American journal of epidemiology · 2022Article
- The value of eosinophil count in the diagnosis of preeclampsia among pregnant women attending the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia, 2021.BMC pregnancy and childbirth · 2022Article
- Evaluation of dyslipidemia in preeclamptic pregnant women and determination of the predictive value of the hemato-lipid profile: A prospective, cross-sectional, case-control study.Turkish journal of obstetrics and gynecology · 2022Article
- Neurovascular dysfunctions in hypertensive disorders of pregnancy.Metabolic brain disease · 2021Review
- The Prenatal Hormone Milieu in Autism Spectrum Disorder.Frontiers in psychiatry · 2021Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAbnormalities of blood cell counts and of cytokine profiles in women with hypertensive disorders of pregnancy (HDP) have been reported in several studies. Although their cause-effect relationships to HDP are not yet clear, detecting and monitoring these alterations can be of use for prognosis and management of HDP. This study aimed to determine hematological, coagulation and cytokine profiles in hypertensive as compared to normotensive pregnancy and to identify correlations between these profiles.
methodsThis was a hospital-based comparative cross-sectional study conducted from September 2017 to February 2018. There were two groups: the comparison group consisted of 77 normotensive pregnant women attending the antenatal clinic of Muhimbili National Hospital (MNH); the index group consisted of 76 hypertensive pregnant women admitted to the maternity block of the same hospital. Hematological and cytokine parameters were compared between the hypertensive and the normotensive group. We analyzed the data using Student's independent t-test when the data were normally distributed; and the Mann-Whitney U-test when the data were not normally distributed. Kruskal Wallis with Dunn's multiple comparison tests was run for subgroup analysis and correlation studies were done using Spearman ranking.
resultsHemoglobin levels were slightly but significantly lower, (P < 0.01) in women with HDP compared to normotensive (N) women; the same was true for platelet counts (P < 0.001). The red cell distribution width (RDW) was slightly but significantly higher in HDP than in N. Neutrophil counts and Interleukin 6 (IL-6) levels were significantly (P < 0.001) higher in HDP than in N; and within HDP IL-6 levels increased with increasing severity of HDP. A novel remarkable finding was that eosinophil counts, normal in N, were lower and lower with increasing severity of HDP, to the point that they were nearly absent in women with eclampsia.
conclusionThere are significant changes in hematological, cytokine and coagulation parameters in pregnant women with hypertensive disorders compared to normotensive pregnant women. The picture that emerges is that of an inflammatory state associated with hypertensive disorders of pregnancy.
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