ArticleProceedings. Biological sciences2019
Premeiotic and meiotic failures lead to hybrid male sterility in the Anopheles gambiae complex.
Article in Proceedings. Biological sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- Sex-specific transcriptome dynamics ofGenes & development · 2025Article
- Unravelling the role of mitochondrial DNA in hybrid incompatibility within species of the Anopheles gambiae complex.Scientific reports · 2024Article
- Review
- Hybridization between Aedes aegypti and Aedes mascarensis mosquitoes leads to disruption of male sex determination.Communications biology · 2024Article
- Y chromosome shredding in Anopheles gambiae: Insight into the cellular dynamics of a novel synthetic sex ratio distorter.PLoS genetics · 2024Article
- Identification and genetic analysis of a pervasive 'needle-eye' sperm phenotype inProceedings. Biological sciences · 2024Article
- Hybridization in an isolated population of blesbok and red hartebeest.Ecology and evolution · 2024Article
- Expression pattern of resynthesized allotetraploid Capsella is determined by hybridization, not whole-genome duplication.The New phytologist · 2023Article
- Unraveling patterns of disrupted gene expression across a complex tissue.Evolution; international journal of organic evolution · 2022Article
- Review
- Reproductive isolation caused by azoospermia in sterile male hybrids ofEcology and evolution · 2020Article
- Article
- Article
- A common suite of cellular abnormalities and spermatogenetic errors in sterile hybrid males inProceedings. Biological sciences · 2020Article
- The Genetic Architecture of Post-Zygotic Reproductive Isolation BetweenFrontiers in genetics · 2020Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hybrid male sterility (HMS) contributes to speciation by restricting gene flow between related taxa. Detailed cytological characterization of reproductive organs in hybrid males is important for identifying phenotypes that can help guide searches of speciation genes. To investigate possible cellular causes of HMS, we performed crosses between closely related species of the Anopheles gambiae complex: An. merus with An. gambiae or An. coluzzii. We demonstrate that HMS in African malaria mosquitoes involves two defects in the reciprocal crosses: a premeiotic arrest of germline stem cells in degenerate testes and a failure of the reductional meiotic division of primary spermatocytes in normal-like testes. The premeiotic arrest in degenerate testes of hybrids is accompanied by a strong suppression of meiotic and postmeiotic genes. Unlike pure species, sex chromosomes in normal-like testes of F1 hybrids are largely unpaired during meiotic prophase I and all chromosomes show various degrees of insufficient condensation. Instead of entering reductional division in meiosis I, primary spermatocytes prematurely undergo an equational mitotic division producing non-motile diploid sperm. Thus, our study identified cytogenetic errors in interspecies hybrids that arise during the early stages of postzygotic isolation.
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