ArticleBiology letters2019
The origin of platelets enabled the evolution of eutherian placentation.
Article in Biology letters, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Placental crises: disruptive selection and maternal under-investment as the foundations of mammalian placental evolution and dysfunction.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Deciphering Platelets: Are They Cells or an Evolved Form of Extracellular Vesicles?Circulation research · 2025Review
- The Implications of Brain-Derived Neurotrophic Factor in the Biological Activities of Platelet-Rich Plasma.Inflammation · 2025Article
- Humanization and functional characterization of enhanced coagulation factor IX variants identified through ancestral sequence reconstruction.Journal of thrombosis and haemostasis : JTH · 2024Article
- Placenta: an old organ with new functions.Frontiers in immunology · 2024Review
- Modifying platelets at their birth: anti-thrombotic therapy without haemorrhage.Frontiers in pharmacology · 2024Review
- Archimetrosis: the evolution of a disease and its extant presentation : Pathogenesis and pathophysiology of archimetrosis (uterine adenomyosis and endometriosis).Archives of gynecology and obstetrics · 2023Article
- A theory of rapid evolutionary change explaining the de novo appearance of megakaryocytes and platelets in mammals.Journal of cell science · 2022Article
- Fate mapping of hematopoietic stem cells reveals two pathways of native thrombopoiesis.Nature communications · 2022Article
- Evolutionary Insight into Immunothrombosis as a Healing Mechanism.International journal of molecular sciences · 2022Article
- Of vascular defense, hemostasis, cancer, and platelet biology: an evolutionary perspective.Cancer metastasis reviews · 2022Review
- Article
- Transposable elements shape the evolution of mammalian development.Nature reviews. Genetics · 2021Review
- Evidence for the loss of plasminogen receptor KT gene in chicken.Immunogenetics · 2020Article
- The Primacy of Maternal Innovations to the Evolution of Embryo Implantation.Integrative and comparative biology · 2020Article
- Platelet Transforming Growth Factor-β1 Induces Liver Sinusoidal Endothelial Cells to Secrete Interleukin-6.Cells · 2020Article
- Maternal Platelets—Friend or Foe of the Human Placenta?International journal of molecular sciences · 2019Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Invasive placentation with extended pregnancy is a shared derived characteristic unique to eutherian mammals that possess a highly effective system of haemostasis, platelets. These are found in all mammals but no other group of animals. We propose that platelets and megakaryocytes (large polyploid nucleated bone marrow cells that produce platelets) evolved from an ancestral 2 N thrombocyte by polyploidization and that the possession of platelets enabled the evolution of invasive placentation. This could explain why invasive placentation is limited to mammals.
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