Evidence map›Paper›PMID 31288577›Full record

ArticleHuman gene therapy2019

Enhancement of MicroRNA-200c on Osteogenic Differentiation and Bone Regeneration by Targeting Sox2-Mediated Wnt Signaling and Klf4.

Adil Akkouch, Steven Eliason, Mason E Sweat, Miguel Romero-Bustillos, Min Zhu, Fang Qian, Brad A Amendt, Liu Hong

Open access · greenAbstract read
In one paragraph

Article in Human gene therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. International journal of molecular sciences · 2025
    Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Exploring microRNAs in craniofacial regenerative medicine.Biochemical Society transactions · 2023
    Review
  11. Review
  12. Article
  13. Plasmid encodingNanomedicine (London, England) · 2022
    Article
  14. Article
  15. MicroRNA-loaded biomaterials for osteogenesis.Frontiers in bioengineering and biotechnology · 2022
    Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Adil AkkouchIowa Institute for Oral Health Research, College of Dentistry, The University of Iowa, Iowa City, Iowa.
Steven EliasonDepartment of Anatomy and Cell Biology, Carver College of Medicine, The University of Iowa, Iowa City, Iowa.
Mason E SweatDepartment of Anatomy and Cell Biology, Carver College of Medicine, The University of Iowa, Iowa City, Iowa.
Miguel Romero-BustillosDepartment of Periodontics, College of Dentistry, The University of Iowa, Iowa City, Iowa.
Min ZhuIowa Institute for Oral Health Research, College of Dentistry, The University of Iowa, Iowa City, Iowa.
Fang QianIowa Institute for Oral Health Research, College of Dentistry, The University of Iowa, Iowa City, Iowa.
Brad A AmendtIowa Institute for Oral Health Research, College of Dentistry, The University of Iowa, Iowa City, Iowa.
Liu HongIowa Institute for Oral Health Research, College of Dentistry, The University of Iowa, Iowa City, Iowa.
University of Iowa · US

Funding

University of Iowa Institutional Training Program in Oral Health ResearchT90DE023520 · NIDCR · UNIVERSITY OF IOWA · PI STEVEN M. LEVY · 2013 to 2026
$5.6M
Oral and Craniofacial Bone Regeneration using MicroRNA ModulationR01DE026433 · NIDCR · UNIVERSITY OF IOWA · PI AMENDT, BRAD A, HONG, LIU · 2017 to 2021
$1.8M
University of Iowa Institutional Training Program in Oral Health ResearchR90DE024296 · NIDCR · UNIVERSITY OF IOWA · PI STEVEN M. LEVY · 2013 to 2026
$1.8M
A microRNA-based Approach for Periodontitis-associated Bone LossR21DE024799 · NIDCR · UNIVERSITY OF IOWA · PI HONG, LIU · 2015 to 2016
$417k
A microRNA-based Approach for Bone RegenerationR21DE025328 · NIDCR · UNIVERSITY OF IOWA · PI HONG, LIU · 2016 to 2017
$410k
NIDCR NIH HHS R01 DE026433NIDCR NIH HHS R21 DE024799NIDCR NIH HHS R21 DE025328NIDCR NIH HHS R90 DE024296
6 · The paper itself

Abstract

MicroRNA (miR)-200c functions in antitumorigenesis and mediates inflammation and osteogenic differentiation. In this study, we discovered that

Indexed as

AnimalsBase SequenceBone RegenerationCell DifferentiationDNAHumansKruppel-Like Factor 4Kruppel-Like Transcription FactorsMaleMesenchymal Stem CellsMice, TransgenicMicroRNAsModels, BiologicalOsteogenesisPlasmidsRats, Sprague-DawleyDNAKLF4 protein, humanKlf4 protein, mouseKlf4 protein, ratKruppel-Like Factor 4Kruppel-Like Transcription FactorsMicroRNAsMIRN200 microRNA, humanSOX2 protein, humanSOXB1 Transcription FactorsboneKlf4miR-200costeogenicSox2Wnt

Identifiers

PMID31288577
PMCPMC6854517
OpenAlexW2961203246

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.