Evidence map›Paper›PMID 31288562›Full record

ArticleAIDS research and human retroviruses2019

Boosting of Markers of Fcγ Receptor Function in Anti-HIV Antibodies During Structured Treatment Interruption.

Hugh Billings, Bruce D Wines, Wayne B Dyer, Robert J Center, Halina M Trist, Stephen J Kent, P Mark Hogarth

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AIDS research and human retroviruses, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 89% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Hugh BillingsImmune Therapies Group, Life Sciences, Burnet Institute, Melbourne, Australia.
Bruce D WinesImmune Therapies Group, Life Sciences, Burnet Institute, Melbourne, Australia.
Wayne B DyerAustralian Red Cross Blood Service, Alexandria, Australia.
Robert J CenterDepartment of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Australia.
Halina M TristImmune Therapies Group, Life Sciences, Burnet Institute, Melbourne, Australia.
Stephen J KentDisease Elimination, Life Sciences, Burnet Institute, Melbourne, Australia.
P Mark HogarthImmune Therapies Group, Life Sciences, Burnet Institute, Melbourne, Australia.
Burnet Institute · AUThe University of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anti-HIV envelope (Env) antibodies elicit important Fc receptor functions, including FcγRIIIa-mediated natural killer cell killing of opsonized infected targets. How these antibodies evolve during HIV infection and treatment remains poorly understood. We describe changes in anti-HIV Env IgG using longitudinal samples from seroconverter subjects treated soon after infection and later during periods of structured treatment interruption (STI). Our well-validated dimeric rsFcγR binding assays combine effects of opsonizing antibody subclasses, epitopes, and geometries to provide a measure of FcγR (Fcγ receptor)-mediated functionality. IgG1 anti-Env titers diminished rapidly during antiretroviral therapy (ART; t

Indexed as

Antigens, ViralBinding Sites, AntibodyEpitopesHIV-1HIV AntibodiesHIV InfectionsHIV SeropositivityHumansImmunity, HumoralImmunoglobulin GLongitudinal StudiesReceptors, IgGAntigens, ViralEpitopesFCGR3A protein, humanHIV AntibodiesImmunoglobulin GReceptors, IgGanti-envelope antibodyARTFc receptor

Identifiers

PMID31288562
PMCPMC6735329
OpenAlexW2962497221

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.