Evidence map›Paper›PMID 31288483›Full record

ArticleGenes2019

Transcriptome Profiling of Primary Skin Fibroblasts Reveal Distinct Molecular Features Between

Pei Jin Lim, Uschi Lindert, Lennart Opitz, Ingrid Hausser, Marianne Rohrbach, Cecilia Giunta

Open access · goldAbstract readComparative Study
In one paragraph

Article in Genes, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Pei Jin LimConnective Tissue Unit, Division of Metabolism and Children's Research Centre, University Children's Hospital, 8032 Zürich, Switzerland.
Uschi LindertConnective Tissue Unit, Division of Metabolism and Children's Research Centre, University Children's Hospital, 8032 Zürich, Switzerland.
Lennart OpitzFunctional Genomics Center Zurich, University of Zurich/ETH Zurich, Winterthurerstrasse 190, 8057 Zürich, Switzerland.
Ingrid HausserInstitute of Pathology, Heidelberg University Hospital, 69120 Heidelberg, Germany.
Marianne RohrbachConnective Tissue Unit, Division of Metabolism and Children's Research Centre, University Children's Hospital, 8032 Zürich, Switzerland. Marianne.Rohrbach@kispi.uzh.ch.
Cecilia GiuntaConnective Tissue Unit, Division of Metabolism and Children's Research Centre, University Children's Hospital, 8032 Zürich, Switzerland. Cecilia.Giunta@kispi.uzh.ch.
University Children's Hospital Zurich · CHHeidelberg University · DEUniversity of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Kyphoscoliotic Ehlers-Danlos Syndrome (kEDS) is a rare genetic heterogeneous disease clinically characterized by congenital muscle hypotonia, kyphoscoliosis, and joint hypermobility. kEDS is caused by biallelic pathogenic variants in either

Indexed as

AdolescentAdultCells, CulturedChildChild, PreschoolEhlers-Danlos SyndromeFemaleFibroblastsGene Expression ProfilingHumansMaleMiddle AgedPeptidylprolyl IsomeraseProcollagen-Lysine, 2-Oxoglutarate 5-DioxygenaseSkinFKBP14 protein, humanPeptidylprolyl IsomerasePLOD1 protein, humanProcollagen-Lysine, 2-Oxoglutarate 5-Dioxygenaseconnective tissueEDS type VIextracellular matrixFKBP14kyphoscoliotic Ehlers–Danlos SyndromePLOD1transcriptomics

Identifiers

PMID31288483
PMCPMC6678841
OpenAlexW2955764133

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.