Evidence map›Paper›PMID 31288417›Full record

ArticleInternational journal of molecular sciences2019

Directed Evolution of P450 BM3 towards Functionalization of Aromatic O-Heterocycles.

Gustavo de Almeida Santos, Gaurao V Dhoke, Mehdi D Davari, Anna Joëlle Ruff, Ulrich Schwaneberg

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
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  4. Article
  5. Article
  6. Article
  7. Frontiers in bioengineering and biotechnology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Gustavo de Almeida SantosLehrstuhl für Biotechnologie, RWTH Aachen University, Worringerweg 3, 52074 Aachen, Germany.
Gaurao V DhokeLehrstuhl für Biotechnologie, RWTH Aachen University, Worringerweg 3, 52074 Aachen, Germany.
Mehdi D DavariLehrstuhl für Biotechnologie, RWTH Aachen University, Worringerweg 3, 52074 Aachen, Germany.ORCID 0000-0003-0089-7156
Anna Joëlle RuffLehrstuhl für Biotechnologie, RWTH Aachen University, Worringerweg 3, 52074 Aachen, Germany.
Ulrich SchwanebergLehrstuhl für Biotechnologie, RWTH Aachen University, Worringerweg 3, 52074 Aachen, Germany. u.schwaneberg@biotec.rwth-aachen.de.

Funding

H2020 Marie Skłodowska-Curie Actions 722390
6 · The paper itself

Abstract

The O-heterocycles, benzo-1,4-dioxane, phthalan, isochroman, 2,3-dihydrobenzofuran, benzofuran, and dibenzofuran are important building blocks with considerable medical application for the production of pharmaceuticals. Cytochrome P450 monooxygenase (P450)

Indexed as

Amino Acid SubstitutionBacillus megateriumBacterial ProteinsBinding SitesBiotransformationCatalysisCytochrome P-450 Enzyme SystemEnzyme ActivationHeterocyclic CompoundsHydroxylationModels, MolecularMolecular ConformationMolecular StructureMutationProtein BindingProtein EngineeringBacterial ProteinsCytochrome P-450 Enzyme SystemHeterocyclic Compoundsdirected evolutionhydroxylationmolecular modelingmonooxygenases aromatic heterocyclesP450protein engineering

Identifiers

PMID31288417
PMCPMC6651506

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.