Evidence map›Paper›PMID 31288395›Full record

SynthesisInternational journal of molecular sciences2019

Diagnostic Roles of Postmortem cTn I and cTn T in Cardiac Death with Special Regard to Myocardial Infarction: A Systematic Literature Review and Meta-Analysis.

Zhipeng Cao, Mengyang Zhao, Chengyang Xu, Tianyi Zhang, Yuqing Jia, Tianqi Wang, Baoli Zhu

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 4 pooled it
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 4 syntheses or guidelines pooled it, 39 citations in OpenAlex.

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  7. Cardiac-specific troponin-I (cTnI) in a post-mortem setting.International journal of legal medicine · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Zhipeng CaoDepartment of Forensic Pathology, School of Forensic Medicine, China Medical University, Shenyang 110122, China.ORCID 0000-0002-4275-0788
Mengyang ZhaoDepartment of Forensic Genetics and Biology, School of Forensic Medicine, China Medical University, Shenyang 110122, China.
Chengyang XuThe Third Clinical Department of China Medical University, Shenyang 110122, China.
Tianyi ZhangDepartment of Forensic Pathology, School of Forensic Medicine, China Medical University, Shenyang 110122, China.
Yuqing JiaDepartment of Forensic Pathology, School of Forensic Medicine, China Medical University, Shenyang 110122, China.
Tianqi WangDepartment of Forensic Pathology, School of Forensic Medicine, China Medical University, Shenyang 110122, China.
Baoli ZhuDepartment of Forensic Pathology, School of Forensic Medicine, China Medical University, Shenyang 110122, China. zhu1127@hotmail.com.ORCID 0000-0001-6083-4187
China Medical University · CN

Funding

National Natural Science Foundation of China 81273343Natural Science Foundation of Liaoning Province 20180530004
6 · The paper itself

Abstract

backgroundCardiac troponin I (cTn I) and cardiac troponin T (cTn T) are currently widely used as diagnostic biomarkers for myocardial injury caused by ischemic heart diseases in clinical and forensic medicine. However, no previous meta-analysis has summarized the diagnostic roles of postmortem cTn I and cTn T. The aim of the present study was to meta-analyze the diagnostic roles of postmortem cTn I and cTn T for cardiac death in forensic medicine, present a systematic review of the previous literature, and determine the postmortem cut-off values of cTn I and cTn T.

methodsWe searched multiple databases for the related literature, performed a meta-analysis to investigate the diagnostic roles of postmortem cardiac troponins, and analyzed the receiver operating characteristic (ROC) curve to determine their postmortem cut-off values. RESULTS AND

conclusionsThe present meta-analysis demonstrated that postmortem cTn I and cTn T levels were increased in pericardial fluid and serum in cardiac death, especially in patients with acute myocardial infarction (AMI). We determined the postmortem cut-off value of cTn I in the pericardial fluid at 86.2 ng/mL, cTn I in serum at 9.5 ng/mL, and cTn T in serum at 8.025 ng/mL.

Indexed as

DeathPostmortem ChangesAutopsyBiomarkersHumansMyocardial InfarctionMyocardiumROC CurveTroponin ITroponin TBiomarkersTroponin ITroponin Tcardiac deathcTn IcTn Tcut-off valueforensic medicinemedical laboratory sciencemeta-analysismyocardial infarctionpostmortempostmortem biochemistry

Identifiers

PMID31288395
PMCPMC6651768
OpenAlexW2955944128

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.