Trial reportThe Journal of thoracic and cardiovascular surgery2019
Near-infrared intraoperative imaging for minimally invasive pulmonary metastasectomy for sarcomas.
Trial report in The Journal of thoracic and cardiovascular surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 37 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Pilot and Feasibility Study of Intraoperative Imagery of Solid Tumors With Indocyanine Green
Sentinel Lymph Node Navigation Using Near-infrared Imaging in Radical Esophagectomy Surgery ：a Single-arm Clinical Trial
Who cites it
37 citing papers in PubMed.
- Feasibility of indocyanine green-guided localization of pulmonary nodules in children with solid tumors.Pediatric blood & cancer · 2023Trial
- Tumor lesion detection in patients with cervical cancer by indocyanine green near-infrared imaging.European journal of nuclear medicine and molecular imaging · 2023Trial
- Multiinstitutional Phase 2 Clinical Trial of Intraoperative Molecular Imaging of Lung Cancer.The Annals of thoracic surgery · 2021Trial
- ICG-based NIR fluorescence imaging can help to detect residual giant cell tumor of bone after intralesional curettage: Results of two-year follow-up.Journal of bone oncology · 2026Article
- Lighting the path: a narrative review of non-molecular intraoperative lung imaging modalities.Journal of thoracic disease · 2026Review
- Article
- Unveiling Macrophage Content as a Predictive Biomarker for Intraoperative ICG Imaging Efficacy in Lung Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- A fibroblast activation protein targeted optical tracer for identifying primary and metastatic sarcoma during resection.EJNMMI research · 2025Article
- Fluorescence imaging-assisted thoracoscopic anatomical lesion resection in treating congenital lung malformation.Scientific reports · 2025Article
- Review
- Advantages and rational application of indocyanine green fluorescence in pulmonary nodule surgery: a narrative review.Journal of thoracic disease · 2024Review
- Dose Optimization of Intravenous Indocyanine Green for Malignant Lung Tumor Localization.Journal of clinical medicine · 2024Article
- Indocyanine green inhalation visualizes lung tumour during video-assisted thoracoscopic surgery.Interdisciplinary cardiovascular and thoracic surgery · 2023Article
- Improving survival after pulmonary metastasectomy for sarcoma: analysis of prognostic factors.General thoracic and cardiovascular surgery · 2023Review
- Application of Indocyanine Green Fluorescence Imaging in Assisting Biopsy of Musculoskeletal Tumors.Cancers · 2023Article
- Intraoperative Evaluation of Soft Tissue Sarcoma Surgical Margins with Indocyanine Green Fluorescence Imaging.Cancers · 2023Article
- Precision Surgery Guided by Intraoperative Molecular Imaging.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022Review
- Intraoperative identification of pulmonary nodules during minimally invasive thoracic surgery: a narrative review.Quantitative imaging in medicine and surgery · 2022Review
- Use of indocyanine green (ICG) fluorescence spectroscopy in thoracoscopic surgery: seeing beyond the unseen.Journal of thoracic disease · 2022Article
- A novel system for analyzing indocyanine green (ICG) fluorescence spectra enables deeper lung tumor localization during thoracoscopic surgery.Journal of thoracic disease · 2022Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
backgroundComplete pulmonary metastasectomy for sarcoma metastases provides patients an opportunity for long-term survival and possible cure. Intraoperative localization of preoperatively identified metastases and identification of occult lesions can be challenging. In this trial, we evaluated the efficacy of near-infrared (NIR) intraoperative imaging using second window indocyanine green during metastasectomy to identify known metastases and to detect occult nodules.
methodsThirty patients with pulmonary nodules suspicious for sarcoma metastases were enrolled in an open-label, feasibility study (NCT02280954). All patients received intravenous indocyanine green (5 mg/kg) 24 hours before metastasectomy. Patients 1 through 10 (cohort 1) underwent metastasectomy via thoracotomy to assess fluorescence patterns of nodules detected by traditional methods (preoperative imaging and intraoperative visualization/bimanual palpation). After confirming reliability within cohort 1, patients 11 through 30 (cohort 2) underwent video-assisted thoracic surgery metastasectomy with NIR imaging.
resultsIn cohort 1, 14 out of 16 preoperatively identified pulmonary metastases (87.5%) displayed tumor fluorescence. Nonfluorescent metastases were deeper than fluorescent metastases (2.1 cm vs 1.3 cm; P = .03). Five out of 5 metastases identified during thoracotomy displayed fluorescence. NIR imaging identified 3 additional occult lesions in this cohort. In cohort 2, 33 out of 37 known pulmonary metastases (89.1%) displayed fluorescence. Nonfluorescent tumors were deeper than 2.0 cm (P = .007). NIR imaging identified 24 additional occult lesions. Of 24 occult lesions, 21 (87.5%) were confirmed metastases and the remaining 3 nodules were lymphoid aggregates.
conclusionsNIR intraoperative imaging with indocyanine green (5 mg/kg and 24 hours before surgery) localizes known sarcoma pulmonary metastases and identifies otherwise occult lesions. This approach may be a useful intraoperative adjunct to improve metastasectomy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.