Evidence map›Paper›PMID 31288042›Full record

ReviewFrontiers in neuroendocrinology2019

Neuroendocrine drivers of risk and resilience: The influence of metabolism & mitochondria.

Susie Turkson, Alix Kloster, Peter J Hamilton, Gretchen N Neigh

Abstract readReview
In one paragraph

Review in Frontiers in neuroendocrinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
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  4. Article
  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Susie TurksonDepartment of Anatomy & Neurobiology, Virginia Commonwealth University, Richmond, VA, United States.
Alix KlosterDepartment of Anatomy & Neurobiology, Virginia Commonwealth University, Richmond, VA, United States.
Peter J HamiltonDepartment of Anatomy & Neurobiology, Virginia Commonwealth University, Richmond, VA, United States.
Gretchen N NeighDepartment of Anatomy & Neurobiology, Virginia Commonwealth University, Richmond, VA, United States. Electronic address: gretchen.mccandless@vcuhealth.org.

Funding

Adult Implications of Chronic Adolescent Stress: Mediators and ModifiersR01NR014886 · NINR · VIRGINIA COMMONWEALTH UNIVERSITY · PI NEIGH, GRETCHEN N · 2014 to 2018
$2.1M
Biological Mechanisms of Stress Disorders Co-Morbid with HIV in African American WomenR01MH110364 · NIMH · VIRGINIA COMMONWEALTH UNIVERSITY · PI JOVANOVIC, TANJA, NEIGH, GRETCHEN N · 2016 to 2020
$2.0M
Engineering CRISPR constructs to elucidate the causal contribution of cell-type specific, gene-targeted CREB binding to the pathogenesis of drug abuseK99DA045795 · NIDA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI HAMILTON, PETER JAMES · 2018 to 2019
$354k
NIDA NIH HHS K99 DA045795NIMH NIH HHS R01 MH110364NINR NIH HHS R01 NR014886
6 · The paper itself

Abstract

The manifestation of risk versus resilience has been considered from varying perspectives including genetics, epigenetics, early life experiences, and type and intensity of the challenge with which the organism is faced. Although all of these factors are central to determining risk and resilience, the current review focuses on what may be a final common pathway: metabolism. When an organism is faced with a perturbation to the environment, whether internal or external, appropriate energy allocation is essential to resolving the divergence from equilibrium. This review examines the potential role of metabolism in the manifestation of stress-induced neural compromise. In addition, this review details the current state of knowledge on neuroendocrine factors which are poised to set the tone of the metabolic response to a systemic challenge. The goal is to provide an essential framework for understanding stress in a metabolic context and appreciation for key neuroendocrine signals.

Indexed as

Resilience, PsychologicalAllostasisAnimalsHormonesHumansHypothalamo-Hypophyseal SystemMitochondriaStress, PsychologicalHormonesAllostasisHomeostasisHormonesMetabolismMitochondriaNeuroendocrineResilienceRiskSex differencesStress

Identifiers

PMID31288042
PMCPMC6886586

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.