Evidence map›Paper›PMID 31287874›Full record

ReviewNucleic acids research2019

DNA nanotechnology approaches for microRNA detection and diagnosis.

Arun Richard Chandrasekaran, Jibin Abraham Punnoose, Lifeng Zhou, Paromita Dey, Bijan K Dey, Ken Halvorsen

Abstract readReview
In one paragraph

Review in Nucleic acids research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed.

  1. Tunable Patterning of DNA Origami on Surfaces Using Steric Brushes.Angewandte Chemie (International ed. in English) · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. High-Throughput Approaches to Engineer Fluorescent Nanosensors.Advanced materials (Deerfield Beach, Fla.) · 2025
    Article
  10. Article
  11. Review
  12. Review
  13. Single-molecule fluorescence methods for protein biomarker analysis.Analytical and bioanalytical chemistry · 2023
    Review
  14. Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Arun Richard ChandrasekaranThe RNA Institute, University at Albany, State University of New York, NY 12222, USA.
Jibin Abraham PunnooseThe RNA Institute, University at Albany, State University of New York, NY 12222, USA.
Lifeng ZhouThe RNA Institute, University at Albany, State University of New York, NY 12222, USA.
Paromita DeyThe RNA Institute, University at Albany, State University of New York, NY 12222, USA.
Bijan K DeyThe RNA Institute, University at Albany, State University of New York, NY 12222, USA.
Ken HalvorsenThe RNA Institute, University at Albany, State University of New York, NY 12222, USA.

Funding

Manipulating nucleic acids: applications in RNA biosensing, single-molecule analysis, and DNA nanotechnologyR35GM124720 · NIGMS · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI Ken A Halvorsen · 2017 to 2026
$4.6M
NIGMS NIH HHS R35 GM124720
6 · The paper itself

Abstract

MicroRNAs are involved in the crucial processes of development and diseases and have emerged as a new class of biomarkers. The field of DNA nanotechnology has shown great promise in the creation of novel microRNA biosensors that have utility in lab-based biosensing and potential for disease diagnostics. In this Survey and Summary, we explore and review DNA nanotechnology approaches for microRNA detection, surveying the literature for microRNA detection in three main areas of DNA nanostructures: DNA tetrahedra, DNA origami, and DNA devices and motifs. We take a critical look at the reviewed approaches, advantages and disadvantages of these methods in general, and a critical comparison of specific approaches. We conclude with a brief outlook on the future of DNA nanotechnology in biosensing for microRNA and beyond.

Indexed as

AnimalsDNAHumansMicroRNAsMolecular Diagnostic TechniquesNanoparticlesNanotechnologyDNAMicroRNAs

Identifiers

PMID31287874
PMCPMC6847506

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.