ArticleEmerging microbes & infections2019
Comprehensive subspecies identification of 175 nontuberculous mycobacteria species based on 7547 genomic profiles.
Article in Emerging microbes & infections, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
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Who cites it
69 citing papers in PubMed, 110 citations in OpenAlex.
- Molecular Characterization of the Air Microbiome and Associated Toxicological Hazards in a Zoological Garden.International journal of molecular sciences · 2026Article
- Comparison of culture and culture-free methods for comprehensive identification of mycobacteria: a single-center prospective study.Journal of clinical microbiology · 2026Article
- Gastric Aspirate Isolate Demonstrates Strain-Level Concordance With Sputum Isolate in Nontuberculous Mycobacterial Pulmonary Disease.Open forum infectious diseases · 2026Article
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- Performance Evaluation of Targeted Nanopore Sequencing in Non-Tuberculous Mycobacteria Identification: A Comparative Study in Shenzhen, China.Infection and drug resistance · 2026Article
- Detection ofVirulence · 2025Article
- Comparative Analysis of Evolutionary Distances Using the GenusInternational journal of molecular sciences · 2025Article
- Molecular epidemiological surveillance for non-tuberculous mycobacterial pulmonary disease: a single-center prospective cohort study.Microbiology spectrum · 2025Article
- Evaluation of mlstverse system for accurate subspecies identification and drug resistance prediction inMicrobiology spectrum · 2025Article
- The Underestimated Threat-Mycobacterium Genavense Infection: A Case Report.Infectious disease reports · 2025Article
- mlstverse-web: advancing real-time identification of mycobacteria from sputum using targeted sequencing NALC-Seq.Functional & integrative genomics · 2025Article
- Whole genome sequence data ofData in brief · 2025Article
- Pulmonary Mycobacterium heckeshornense Infection in which the Causative Microorganism Was Difficult to Identify.Internal medicine (Tokyo, Japan) · 2025Article
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- Biochip-Based Identification of Mycobacterial Species in Russia.International journal of molecular sciences · 2024Article
- A framework for exclusion of alternative diagnoses in sarcoidosis.Journal of autoimmunity · 2024Review
- Exploring the Chemical Space of Mycobacterial Oxidative Phosphorylation Inhibitors Using Molecular Modeling.ChemMedChem · 2024Review
- Nontuberculous Mycobacterial Infections: A Retrospective Analysis From a Tertiary Hospital in Portugal.Cureus · 2024Article
9 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The prevalence of nontuberculous mycobacteria (NTM) pulmonary diseases has been increasing worldwide. NTM consist of approximately 200 species and distinguishing between them at the subspecies level is critical to treatment. In this study, we sequenced 63 NTM genomes, 27 of which were newly determined, by hybrid assembly using sequencers from Illumina and Oxford Nanopore Technologies (ONT). This analysis expanded the available genomic data to 175 NTM species and redefined their subgenus classification. We also developed a novel multi-locus sequence typing (MLST) database based on 184 genes from 7547 assemblies and an identification software, mlstverse, which can also be used for detecting other bacteria given a suitable MLST database. This method showed the highest sensitivity and specificity amongst conventional methods and demonstrated the capacity for rapid detection of NTM, 10 min of sequencing of the ONT MinION being sufficient. Application of this methodology could improve disease epidemiology and increase the cure rates of NTM diseases.
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