Evidence map›Paper›PMID 31287754›Full record

ReviewHuman vaccines & immunotherapeutics2020

Functional antibodies as immunological endpoints to evaluate protective immunity against

Esther Ndungo, Marcela F Pasetti

Abstract readReview
In one paragraph

Review in Human vaccines & immunotherapeutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Trial
  4. Antibodies Elicited by theFrontiers in immunology · 2021
    Trial
  5. Trial
  6. Multifunctional antibody responses from a primateScience translational medicine · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Oral immunization withmSphere · 2024
    Article
  15. Shigella-Controlled Human Infection Models: Current and Future Perspectives.Current topics in microbiology and immunology · 2024
    Review
  16. Article
  17. Comparison ofFrontiers in molecular biosciences · 2023
    Article
  18. Functional assays to evaluate antibody-mediated responses againstFrontiers in cellular and infection microbiology · 2023
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Esther NdungoCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-9975-7032
Marcela F PasettiCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID 0000-0003-0894-4009

Funding

Research Training in Gastroenterology and HepatologyT32DK067872 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI RAUFMAN, JEAN-PIERRE · 2005 to 2024
$7.2M
Serological assays to predict Shigella vaccine efficacyR01AI125841 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI PASETTI, MARCELA F · 2016 to 2020
$2.8M
Vaccines and maternally acquired immunity to prevent shigellosis in childrenR01AI117734 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI PASETTI, MARCELA F · 2015 to 2019
$2.0M
NIAID NIH HHS R01 AI117734NIAID NIH HHS R01 AI125841NIDDK NIH HHS T32 DK067872
6 · The paper itself

Abstract

The development, clinical advancement and licensure of vaccines, and monitoring of vaccine effectiveness could be expedited and simplified by the ability to measure immunological endpoints that can predict a favorable clinical outcome. Antigen-specific and functional antibodies have been described in the context of naturally acquired immunity and vaccination against

Indexed as

Adaptive ImmunityAntibodies, BacterialDysentery, BacillaryHumansShigellaShigella VaccinesVaccinationAntibodies, BacterialShigella Vaccinescorrelates of protectionFunctional antibodiesprotective immunityShigellathreshold of protectiontrials for developing countriesvaccinology

Identifiers

PMID31287754
PMCPMC7670857

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.