Evidence map›Paper›PMID 31287737›Full record

ArticleThe British journal of radiology2019

Spect perfusion imaging versus CT for predicting radiation injury to normal lung in lung cancer patients.

Alex Weller, Alex Dunlop, Adam Oxer, Ranga Gunapala, Iain Murray, Matthew J Gray, Glenn D Flux, Nandita M deSouza, Merina Ahmed

Abstract readComparative Study
In one paragraph

Article in The British journal of radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Alex Weller1The CRUK Cancer Imaging Centre, The Institute of Cancer Research and The Royal Marsden Hospital NHS Foundation Trust, Sutton, Surrey.
Alex Dunlop3The Joint Department of Physics, The Royal Marsden Hospital NHS Foundation Trust and The Institute of Cancer Research, Sutton, Surrey.
Adam Oxer4The Royal Marsden Hospital NHS Foundation Trust, Sutton, Surrey.
Ranga Gunapala4The Royal Marsden Hospital NHS Foundation Trust, Sutton, Surrey.
Iain Murray3The Joint Department of Physics, The Royal Marsden Hospital NHS Foundation Trust and The Institute of Cancer Research, Sutton, Surrey.
Matthew J Gray3The Joint Department of Physics, The Royal Marsden Hospital NHS Foundation Trust and The Institute of Cancer Research, Sutton, Surrey.
Glenn D Flux3The Joint Department of Physics, The Royal Marsden Hospital NHS Foundation Trust and The Institute of Cancer Research, Sutton, Surrey.
Nandita M deSouza1The CRUK Cancer Imaging Centre, The Institute of Cancer Research and The Royal Marsden Hospital NHS Foundation Trust, Sutton, Surrey.ORCID http://orcid.org/0000-0003-4232-476X
Merina Ahmed4The Royal Marsden Hospital NHS Foundation Trust, Sutton, Surrey.

Funding

Cancer Research UK 16464Cancer Research UK 19727
6 · The paper itself

Abstract

objectivesIn non-small cell lung cancer (NSCLC) patients, to establish whether the fractional volumes of irradiated anatomic or perfused lung differed between those with and without deteriorating lung function or radiation associated lung injury (RALI).

methods48 patients undergoing radical radiotherapy for NSCLC had a radiotherapy-planning CT scan and single photon emission CT lung perfusion imaging (

resultsFractional volumes of anatomic and perfused lung receiving more than 10, 13 and 20 Gy were significantly higher in patients with deteriorating

conclusionA 10-20 Gy radiation dose to anatomic or perfused lung results in decline in FEV1. A fractional anatomic volume of >5% receiving >50 Gy influences development of RALI. ADVANCES IN KNOWLEDGE: Extent of low-dose radiation to normal lung influences functional respiratory decline.

Indexed as

AgedAged, 80 and overCarcinoma, Non-Small-Cell LungFemaleHumansLungLung NeoplasmsMaleMiddle AgedPredictive Value of TestsRadiation InjuriesRadiotherapy DosageRadiotherapy Planning, Computer-AssistedTomography, Emission-Computed, Single-PhotonTomography, X-Ray Computed

Identifiers

PMID31287737
PMCPMC6732923

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.