ArticleThe American journal of tropical medicine and hygiene2019
Risk Factors for Mortality in Severely Ill Children Admitted to a Tertiary Referral Hospital in Malawi.
Article in The American journal of tropical medicine and hygiene, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Prevalence and risk factors of under-five mortality due to severe acute malnutrition in Africa: a systematic review and meta-analysis.Systematic reviews · 2025Pooled it
- Mortality impact of an increased blood glucose cut-off level for hypoglycaemia treatment in severely sick children aged 5 to 12 years in Malawi - an exploratory randomised controlled study.BMC pediatrics · 2026Trial
- Consequences of post-discharge hospitalisation on the growth of young Bangladeshi children hospitalised with diarrhoea: a secondary case-control analysis of Antibiotics for Children with Diarrhea (ABCD) trial.Journal of global health · 2025Trial
- Low Blood Glucose and Its Relation to Electrolyte Derangements and Metabolic Acidosis in Critically Ill Children in Malawi.The American journal of tropical medicine and hygiene · 2026Article
- Pathways of emergency care for severely ill children in Nigerian and Ugandan hospitals: A process mapping study.PLoS medicine · 2026Article
- Article
- Comprehensive assessment of pediatric acute and inpatient care at a tertiary referral hospital in Malawi: opportunities for quality improvement.BMJ paediatrics open · 2024Article
- Paediatric Emergency Care in Low-Income Countries-Can Guidelines be Generalized?Global pediatric health · 2024Article
- Critical illness at the emergency department of a Tanzanian national hospital in a three-year period 2019-2021.BMC emergency medicine · 2023Article
- Mortality by Admission Diagnosis in Children 1-60 Months of Age Admitted to a Tertiary Care Government Hospital in Malawi.The American journal of tropical medicine and hygiene · 2023Article
- Prospective cohort study of referred Malawian children and their survival by hypoxaemia and hypoglycaemia status.Bulletin of the World Health Organization · 2022Article
- Factors associated with in-hospital mortality of patients admitted to an intensive care unit in a tertiary hospital in Malawi.PloS one · 2022Article
- Hypoxemia, hypoglycemia and IMCI danger signs in pediatric outpatients in Malawi.PLOS global public health · 2022Article
- Improving management of hypoglycaemia in children.Bulletin of the World Health Organization · 2021Article
- The Association of Low Blood Glucose and Low Serum Cortisol Levels in Severely Ill Children Admitted to Tertiary Referral Hospitals in Malawi: A Case-Control Study.The American journal of tropical medicine and hygiene · 2021Article
- Paediatric Emergency Triage, Assessment and Treatment (ETAT) - preparedness for implementation at primary care facilities in Malawi.Global health action · 2021Article
- Predictive value of pulse oximetry for mortality in infants and children presenting to primary care with clinical pneumonia in rural Malawi: A data linkage study.PLoS medicine · 2020Article
- Feeding practices and association of fasting and low or hypo glycaemia in severe paediatric illnesses in Malawi - a mixed method study.BMC pediatrics · 2020Article
- Barriers to Pediatric Emergency Care in Low-Resource Settings: A Narrative Review.Sage open pediatricsReview
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In low-resource settings, many children are severely ill at arrival to hospital. The risk factors for mortality among such ill children are not well-known. Understanding which of these patients are at the highest risk could assist in the allocation of limited resources to where they are most needed. A cohort study of severely ill children treated in the resuscitation room of the pediatric emergency department at Queen Elizabeth Central Hospital in Malawi was conducted over a 6-month period in 2017. Data on signs and symptoms, vital signs, blood glucose levels, and nutritional status were collected and linked with in-hospital mortality data. The factors associated with in-hospital mortality were analyzed using multivariable logistic regression. Data for 1,359 patients were analyzed and 118 (8.7%) patients died. The following factors were associated with mortality: presence of any severely deranged vital sign, unadjusted odds ratio (UOR) 2.6 (95% CI 1.7-4.0) and adjusted odds ratio (AOR) 3.2 (95% CI 2.0-5.0); severe dehydration, UOR 2.6 (1.4-5.1) and AOR 2.8 (1.3-6.0); hypoglycemia glycemia (< 5 mmol/L), UOR 3.6 (2.2-5.8) and AOR 2.7 (1.6-4.7); and severe acute malnutrition, UOR 5.8 (3.5-9.6) and AOR 5.7 (3.3-10.0). This study suggests that among severely sick children, increased attention should be given to those with hypo/low glycemia, deranged vital signs, malnutrition, and severe dehydration to avert mortality among these high-risk patients.
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