Evidence map›Paper›PMID 31286974›Full record

SynthesisJournal of neuroengineering and rehabilitation2019

Does transcranial direct current stimulation improve functional locomotion in people with Parkinson's disease? A systematic review and meta-analysis.

Hyo Keun Lee, Se Ji Ahn, Yang Mi Shin, Nyeonju Kang, James H Cauraugh

Erratum issuedOpen access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of neuroengineering and rehabilitation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 26 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 8 pooled it
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 8 syntheses or guidelines pooled it, 68 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Hyo Keun LeeDivision of Sport Science, Neuromechanical Rehabilitation Research Laboratory, Incheon National University, 119 Academy-ro, Yeonsu-gu, Incheon, South Korea.
Se Ji AhnDivision of Sport Science, Neuromechanical Rehabilitation Research Laboratory, Incheon National University, 119 Academy-ro, Yeonsu-gu, Incheon, South Korea.
Yang Mi ShinDivision of Sport Science, Neuromechanical Rehabilitation Research Laboratory, Incheon National University, 119 Academy-ro, Yeonsu-gu, Incheon, South Korea.
Nyeonju KangDivision of Sport Science, Neuromechanical Rehabilitation Research Laboratory, Incheon National University, 119 Academy-ro, Yeonsu-gu, Incheon, South Korea. nyunju@inu.ac.kr.ORCID 0000-0003-4440-4413
James H CauraughDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida, USA.
Incheon National University · KRUniversity of Florida · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe purpose of this meta-analysis was to investigate the treatment effects of transcranial direct current stimulation (tDCS) on functional locomotion in people with Parkinson's disease (PD).

methodsA systematic literature search identified 18 qualified studies that used tDCS protocols as functional locomotion rehabilitation interventions for people with PD. All included studies used either a randomized control trial or crossover designs with a sham control group. Meta-analysis quantified both (a) short-term treatment effects: change in functional locomotion between baseline and immediate posttests on 18 comparisons and (b) long-term treatment effects: change in functional locomotion between baseline and delayed retention tests on six comparisons. Moreover, we performed moderator variable analyses for comparing effect sizes between tDCS targeting multiple brain regions and tDCS targeting a single brain region.

resultsRandom effects model meta-analyses revealed a significant short-term treatment effect (effect size = 0.359; P = 0.001), whereas no significant long-term treatment effects were identified (effect size = 0.164; P = 0.314). In addition, tDCS protocols that targeted multiple brain regions showed relatively more positive effects on functional locomotion than protocols that targeted a single brain region.

conclusionsThese meta-analytic findings indicate that tDCS protocols may show immediate positive effects on functional locomotion in people with PD. However, given the relatively low effect size, exploring more appropriate tDCS protocols (i.e., targeting multiple motor and prefrontal regions and medication condition) should be a focus in future studies.

Indexed as

BrainHumansLocomotionParkinson DiseaseTranscranial Direct Current StimulationFunctional locomotionMeta-analysisParkinson’s diseaseTranscranial direct current stimulation

Identifiers

PMID31286974
PMCPMC6615099
OpenAlexW2962201826

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.