ArticleBMC complementary and alternative medicine2019
Leaf extract of Caesalpinia mimosoides enhances oxidative stress resistance and prolongs lifespan in Caenorhabditis elegans.
Article in BMC complementary and alternative medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed.
- Integrative computational analysis of anti-influenza potential in Caesalpinia mimosoides Lamk hydroethanolic extract.Scientific reports · 2025Article
- Protective effects of tiger milk mushroom extract (xLr®) against UVB irradiation inJournal of traditional and complementary medicine · 2025Article
- Phytochemical Screening, Antibacterial Activity, and Toxicity ofPreventive nutrition and food science · 2024Article
- Coniferaldehyde activates autophagy and enhances oxidative stress resistance and lifespan of Caenorhabditis elegans via par-4/aak-2/skn-1 pathway.Biogerontology · 2024Article
- Effects ofMolecules (Basel, Switzerland) · 2024Article
- Leaf extract ofFrontiers in pharmacology · 2024Article
- Bee Venom Toxic Effect on MDA-MB-231 Breast Cancer Cells andAnti-cancer agents in medicinal chemistry · 2024Article
- Unveiling the Potent Antiviral and Antioxidant Activities of an Aqueous Extract fromFoods (Basel, Switzerland) · 2023Article
- Phytochemical Profiling and Antioxidant Capacity of Traditional Plants, Northern Thailand.Plants (Basel, Switzerland) · 2023Article
- Protective Effect ofNutrients · 2023Article
- Effects of Vegetal Extracts and Metabolites against Oxidative Stress and Associated Diseases: Studies inACS omega · 2023Review
- Polygonati Rhizoma Polysaccharide Prolongs Lifespan and Healthspan inMolecules (Basel, Switzerland) · 2023Article
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- 2-Butoxytetrahydrofuran and Palmitic Acid fromPharmaceuticals (Basel, Switzerland) · 2022Article
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- Development and characterization of chlorophyll-amended montmorillonite clays for the adsorption and detoxification of benzene.Water research · 2022Article
- Stress Buffering and Longevity Effects of Amber Extract onMolecules (Basel, Switzerland) · 2022Article
- A Fat-Promoting Botanical Extract From Artemisia scoparia Exerts Geroprotective Effects on Caenorhabditis elegans Life Span and Stress Resistance.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
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Authors and funding
7 authors.
Funding
Abstract
backgroundCaesalpinia mimosoides, a vegetable consumed in Thailand, has been reported to exhibit in vitro antioxidant properties. The in vivo antioxidant and anti-aging activities have not been investigated. The aim of this research was to study the antioxidant activity of C. mimosoides extracts in Caenorhabditis elegans, a widely used model organism in this context.
methodsC. elegans were treated with C. mimosoides extracts in a various concentrations. To investigate the protective effects of the extract against oxidative stress, wild-type N2 were used to determine survival rate under oxidative stress and intracellular ROS. To study underlying mechanisms, the mutant strains with GFP reporter gene including TJ356, CF1553, EU1 and LD4 were used to study DAF-16, SOD-3, SKN-1 and GST-4 gene, respectively. Lifespan and aging pigment of the worms were also investigated.
resultsA leaf extract of C. mimosoides improved resistance to oxidative stress and reduced intracellular ROS accumulation in nematodes. The antioxidant effects were mediated through the DAF-16/FOXO pathway and SOD-3 expression, whereas the expression of SKN-1 and GST-4 were not altered. The extract also prolonged lifespan and decreased aging pigments, while the body length and brood size of the worms were not affected by the extract, indicating low toxicity and excluding dietary restriction.
conclusionsThe results of this study establish the antioxidant activity of C. mimosoides extract in vivo and suggest its potential as a dietary supplement and alternative medicine to defend against oxidative stress and aging, which should be investigated in intervention studies.
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