Evidence map›Paper›PMID 31286941›Full record

ArticleBMC complementary and alternative medicine2019

Rosmarinic acid improves hypertension and skeletal muscle glucose transport in angiotensin II-treated rats.

Mujalin Prasannarong, Vitoon Saengsirisuwan, Juthamard Surapongchai, Jariya Buniam, Natsasi Chukijrungroat, Yupaporn Rattanavichit

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC complementary and alternative medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Mujalin PrasannarongDepartment of Physical Therapy, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, 50200, Thailand. mujalin.p@cmu.ac.th.ORCID http://orcid.org/0000-0003-2820-3929
Vitoon SaengsirisuwanExercise Physiology Laboratory, Department of Physiology, Faculty of Science, Mahidol University, Bangkok, 10400, Thailand.
Juthamard SurapongchaiFaculty of Physical Therapy, Mahidol University, Nakhonpathom, 73170, Thailand.
Jariya BuniamExercise Physiology Laboratory, Department of Physiology, Faculty of Science, Mahidol University, Bangkok, 10400, Thailand.
Natsasi ChukijrungroatFaculty of Physical Therapy, Huachiew Chalermprakiet University, Samut Prakan, 10540, Thailand.
Yupaporn RattanavichitDivision of Physical Therapy, Faculty of Physical Therapy, Srinakharinwirot University, Nakhon Nayok, 26120, Thailand.
Mahidol University · THChiang Mai University · THHuachiew Chalermprakiet University · THSrinakharinwirot University · TH

Funding

Thailand Research Fund TRG5680065
6 · The paper itself

Abstract

backgroundRosmarinic acid (RA) is a natural pure compound from herbs belonging to the Lamiaceae family, such as rosemary, sage, basil, and mint. The antioxidant, angiotensin-converting enzyme inhibitory, and vasodilatory effects of RA have been revealed. Angiotensin II (ANG II) is a potent agent that generates hypertension and oxidative stress. Hypertension and skeletal muscle insulin resistance are strongly related. The aim of this study was to evaluate the effects of acute and chronic RA treatment on blood pressure and skeletal muscle glucose transport in ANG II-induced hypertensive rats.

methodsEight-week-old male Sprague Dawley rats were separated into SHAM and ANG II-infused (250 ng/kg/min) groups. ANG II rats were treated with or without acute or chronic RA at 10, 20, or 40 mg/kg. At the end of the experiment, body weight, liver and heart weights, oral glucose tolerance, skeletal muscle glucose transport activity, and signaling proteins were evaluated.

resultsBoth acute and chronic RA treatment decreased systolic, diastolic, and mean arterial blood pressure. Only acute RA at 40 mg/kg resulted in a reduction of fasting plasma glucose levels and an induction of skeletal muscle glucose transport activity. These effects might involve increased ERK activity in skeletal muscle. Meanwhile, chronic RA treatment with 10, 20, and 40 mg/kg prevented ANG II-induced hyperglycemia.

conclusionsBoth acute and chronic RA treatment attenuated ANG II-induced cardiometabolic abnormalities in rats. Therefore, RA would be an alternative strategy for improving skeletal muscle glucose transport and protecting against ANG II-induced hypertension and hyperglycemia.

Indexed as

Angiotensin IIAnimalsBlood PressureBody WeightCinnamatesDepsidesGlucoseHypertensionInsulinMaleMuscle, SkeletalOrgan SizeRatsRats, Sprague-DawleyRosmarinic AcidSignal TransductionAngiotensin IICinnamatesDepsidesGlucoseInsulinRosmarinic AcidAngiotensin IIExtracellular signal-regulated kinaseInsulin resistanceMitogen-activated protein kinaseRosmarinic acidSkeletal muscle

Identifiers

PMID31286941
PMCPMC6615279
OpenAlexW2959156464

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.