ArticleEMBO reports2019
Multiple C2 domains and transmembrane region proteins (MCTPs) tether membranes at plasmodesmata.
Article in EMBO reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers, 1 of them a synthesis that pooled it.
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Who cites it
82 citing papers in PubMed, 1 synthesis or guideline pooled it, 152 citations in OpenAlex.
- A comparative meta-proteomic pipeline for the identification of plasmodesmata proteins and regulatory conditions in diverse plant species.BMC biology · 2022Pooled it
- A STRUBBELIG-NHL3 cell surface receptor complex mediates the response to cellulose deficiency in Arabidopsis.Nature plants · 2026Article
- Highly Polygenic Control of Photosynthetic Responses to Nighttime Temperature Studied by Genomic Prediction.Plant, cell & environment · 2026Article
- Interspecific secondary plasmodesmata at the parasitic interface.Plant & cell physiology · 2026Review
- MCTP1 and MCTP2 promote ER-PM contact sites and regulate PI4P homeostasis and cell migration.Molecular biology of the cell · 2026Article
- In situ architecture of plasmodesmata in Physcomitrium patens resolved by cryo-electron tomography.Nature plants · 2026Article
- The influence of electrical charge on plasmodesma conductivity.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Genome-Wide Identification of theInternational journal of molecular sciences · 2026Article
- Quantification of cell-type-specific plasmodesmata distribution in Arabidopsis roots reveals spatial and patterning dynamics.The Plant journal : for cell and molecular biology · 2026Article
- Motif-based substrate mapping of the receptor-like cytoplasmic kinase BIK1 reveals novel components and regulatory nodes of plant immunity.Nature plants · 2026Article
- Plasmodesmata wall biomechanics: challenges and opportunities.Journal of experimental botany · 2026Review
- Should I stay or should I go-does protein localization to plasmodesmata depend on targeting signals?Journal of experimental botany · 2026Article
- The study of plasmodesmal biology using proximity labeling technologies.Journal of experimental botany · 2026Review
- Comparative transcriptomics of anthocyanin accumulation in the pericarp of pigmented purple corn.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- The CELL NUMBER REGULATOR SlFWL5 protein regulates aerial vegetative growth in tomato, by promoting cell expansion.Journal of experimental botany · 2026Article
- QUIRKY controls seed germination via precision degradation of ABI5.Science advances · 2025Article
- SUPPRESSOR OF LAZY QUADRUPLE 1 acts at ER-plasma membrane contact sites to control a gravitropism pathway in theProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Complex sphingolipid metabolism impacts cell division and plasmodesmal development in the moss Physcomitrium patens.Plant physiology · 2025Article
- Cell-to-cell translocation of florigen is inhibited by low ambient temperature through abscisic acid signaling inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Viral tropism in plants, reproductive tissues, and seeds.Archives of microbiology · 2025Review
22 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors at 8 institutions in 4 countries.
Funding
Abstract
In eukaryotes, membrane contact sites (MCS) allow direct communication between organelles. Plants have evolved a unique type of MCS, inside intercellular pores, the plasmodesmata, where endoplasmic reticulum (ER)-plasma membrane (PM) contacts coincide with regulation of cell-to-cell signalling. The molecular mechanism and function of membrane tethering within plasmodesmata remain unknown. Here, we show that the multiple C2 domains and transmembrane region protein (MCTP) family, key regulators of cell-to-cell signalling in plants, act as ER-PM tethers specifically at plasmodesmata. We report that MCTPs are plasmodesmata proteins that insert into the ER via their transmembrane region while their C2 domains dock to the PM through interaction with anionic phospholipids. A Atmctp3/Atmctp4 loss of function mutant induces plant developmental defects, impaired plasmodesmata function and composition, while MCTP4 expression in a yeast Δtether mutant partially restores ER-PM tethering. Our data suggest that MCTPs are unique membrane tethers controlling both ER-PM contacts and cell-to-cell signalling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.