Evidence map›Paper›PMID 31286573›Full record

ReviewAdvanced materials (Deerfield Beach, Fla.)2020

Integrating Artificial Intelligence and Nanotechnology for Precision Cancer Medicine.

Omer Adir, Maria Poley, Gal Chen, Sahar Froim, Nitzan Krinsky, Jeny Shklover, Janna Shainsky-Roitman, Twan Lammers, Avi Schroeder

Abstract readReview
In one paragraph

Review in Advanced materials (Deerfield Beach, Fla.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 166 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
166citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

166 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  6. Mesoporous Silica Nanoparticles in Biomedicine: Advances and Prospects.Advanced materials (Deerfield Beach, Fla.) · 2026
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106 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Omer AdirDepartment of Chemical Engineering, Technion - Israel Institute of Technology, Haifa, 3200003, Israel.
Maria PoleyDepartment of Chemical Engineering, Technion - Israel Institute of Technology, Haifa, 3200003, Israel.
Gal ChenDepartment of Chemical Engineering, Technion - Israel Institute of Technology, Haifa, 3200003, Israel.
Sahar FroimDepartment of Physical Electronics, School of Electrical Engineering, Fleischman Faculty of Engineering, Tel Aviv University, Tel Aviv, 69978, Israel.
Nitzan KrinskyDepartment of Chemical Engineering, Technion - Israel Institute of Technology, Haifa, 3200003, Israel.
Jeny ShkloverDepartment of Chemical Engineering, Technion - Israel Institute of Technology, Haifa, 3200003, Israel.
Janna Shainsky-RoitmanDepartment of Chemical Engineering, Technion - Israel Institute of Technology, Haifa, 3200003, Israel.
Twan LammersInstitute for Experimental Molecular Imaging, RWTH Aachen University Hospital, Aachen, 52074, Germany.
Avi SchroederDepartment of Chemical Engineering, Technion - Israel Institute of Technology, Haifa, 3200003, Israel.ORCID https://orcid.org/0000-0003-2571-5937

Funding

ERC STG-2015-680242European Research Council 680242European Union FP-7 IRG Program for a Career Integration 908049FP7 Science in Society 908049German-Israeli Foundation for Scientific Research and Development I-2328-1139.10/2012German-Israeli Foundation for Scientific Research and Development for a GIF Young I-2328-1139.10/2012Israel Cancer Association 2015-0116Israel Ministry of Economy for a Kamin 52752Israel Ministry of Science Technology and Space - Office of the Chief Scientist 3-11878Israel Science Foundation 1421/17Israel Science Foundation 1778/13Lorry I. Lokey Interdisciplinary Center for Life Sciences and Engineering, Technion-Israel Institute of TechnologyLorry I. Lokey Interdisciplinary Center for Life Sciences & EngineeringMallat Family FoundationMinistry of Economy 52752Ministry of Science and Technology, Israel 3-11878Phospholipid Research CenterRussell Berrie Nanotechnology InstituteRussell Berrie Nanotechnology Institute, Technion-Israel Institute of TechnologyTechnion Integrated Cancer CenterUnger Family Fund
6 · The paper itself

Abstract

Artificial intelligence (AI) and nanotechnology are two fields that are instrumental in realizing the goal of precision medicine-tailoring the best treatment for each cancer patient. Recent conversion between these two fields is enabling better patient data acquisition and improved design of nanomaterials for precision cancer medicine. Diagnostic nanomaterials are used to assemble a patient-specific disease profile, which is then leveraged, through a set of therapeutic nanotechnologies, to improve the treatment outcome. However, high intratumor and interpatient heterogeneities make the rational design of diagnostic and therapeutic platforms, and analysis of their output, extremely difficult. Integration of AI approaches can bridge this gap, using pattern analysis and classification algorithms for improved diagnostic and therapeutic accuracy. Nanomedicine design also benefits from the application of AI, by optimizing material properties according to predicted interactions with the target drug, biological fluids, immune system, vasculature, and cell membranes, all affecting therapeutic efficacy. Here, fundamental concepts in AI are described and the contributions and promise of nanotechnology coupled with AI to the future of precision cancer medicine are reviewed.

Indexed as

Artificial IntelligenceAnimalsComputational BiologyDrug Delivery SystemsHumansNanomedicineNanostructuresNanotechnologyNeoplasmsPrecision Medicineartificial intelligencebig datacancernanotechnologyprecision medicine

Identifiers

PMID31286573
PMCPMC7124889

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.