ArticleJournal of pineal research2019
Melatonin is a potential drug for the prevention of bone loss during space flight.
Article in Journal of pineal research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 85 citations in OpenAlex.
- Stability of Medicinal Nanoemulsions to Spaceflight: Insights From the StarMed Experiment.Advanced healthcare materials · 2026Article
- Melatonin Counteracts Mechanical Unloading-Induced Bone Loss Through YTHDF3-Mediated mJournal of pineal research · 2026Article
- Spaceflight alters molecular networks linked to diverse human diseases in a single cellular model.Science advances · 2026Article
- Melatonin suppresses the plasma calcium level in female goldfish during the late and post-reproductive stages.Scientific reports · 2025Article
- Melatonin: A Potential Therapy for Osteoporosis With Insights Into Molecular Mechanisms.Journal of pineal research · 2025Review
- Targeted disruption of the aralkylaminePNAS nexus · 2025Article
- Genes involved in osteogenic differentiation induced by low‑intensity pulsed ultrasound in goldfish scales.Biomedical reports · 2025Article
- Melatonin antagonizes bone loss induced by mechanical unloading via IGF2BP1-dependent mCellular and molecular life sciences : CMLS · 2025Article
- Melatonin Regulates Osteoblast Differentiation through the m6A Reader hnRNPA2B1 under Simulated Microgravity.Current issues in molecular biology · 2024Article
- Consideration of hormonal changes for orthodontic treatment during pregnancy and lactation - a review.Reproductive biology and endocrinology : RB&E · 2024Review
- Dietary melatonin and liver cancer incidence in Japan: From the Takayama study.Cancer science · 2024Article
- Kynurenine promotes Calcitonin secretion and reduces cortisol in the Japanese flounder Paralichthys olivaceus.Scientific reports · 2023Article
- Adaptation to the shallow sea floor environment of a species of marine worms, Oligobrachia mashikoi, generally inhabiting deep-sea water.Scientific reports · 2023Article
- Melatonin suppresses bone marrow adiposity in ovariectomized rats by rescuing the imbalance between osteogenesis and adipogenesis through SIRT1 activation.Journal of orthopaedic translation · 2023Article
- Pyroptosis in Periprosthetic Osteolysis.Biomolecules · 2022Review
- Review
- The Protective Role of 4-Acetylarylquinolinol B in Different Pathological Processes.Current issues in molecular biology · 2022Review
- The effects of microgravity on bone structure and function.NPJ microgravity · 2022Review
- The role of circadian rhythm in osteoporosis; a review.Frontiers in cell and developmental biology · 2022Review
- Glyoxal-induced formation of advanced glycation end-products in type 1 collagen decreases both its strength and flexibility in vitro.Journal of diabetes investigation · 2021Article
Corrections and comments
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Authors and funding
53 authors at 20 institutions in 2 countries.
Funding
Abstract
Astronauts experience osteoporosis-like loss of bone mass because of microgravity conditions during space flight. To prevent bone loss, they need a riskless and antiresorptive drug. Melatonin is reported to suppress osteoclast function. However, no studies have examined the effects of melatonin on bone metabolism under microgravity conditions. We used goldfish scales as a bone model of coexisting osteoclasts and osteoblasts and demonstrated that mRNA expression level of acetylserotonin O-methyltransferase, an enzyme essential for melatonin synthesis, decreased significantly under microgravity. During space flight, microgravity stimulated osteoclastic activity and significantly increased gene expression for osteoclast differentiation and activation. Melatonin treatment significantly stimulated Calcitonin (an osteoclast-inhibiting hormone) mRNA expression and decreased the mRNA expression of receptor activator of nuclear factor κB ligand (a promoter of osteoclastogenesis), which coincided with suppressed gene expression levels for osteoclast functions. This is the first study to report the inhibitory effect of melatonin on osteoclastic activation by microgravity. We also observed a novel action pathway of melatonin on osteoclasts via an increase in CALCITONIN secretion. Melatonin could be the source of a potential novel drug to prevent bone loss during space flight.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.