ArticleJournal of orthopaedic research : official publication of the Orthopaedic Research Society2020
Tendon Biomechanics and Crimp Properties Following Fatigue Loading Are Influenced by Tendon Type and Age in Mice.
Article in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Structural Variations of Tendons: A Systematic Search and Narrative Review of Histological Differences Between Tendons, Tendon Regions, Sex, and Age.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025Pooled it
- Epigenetic mechanisms in Tendon Ageing.British medical bulletin · 2020Pooled it
- Creb3l1 Overexpression Improves Flexor Tendon Repair in Aged Rats.Aging cell · 2026Article
- Characterizing tendon microstructure using metrics associated with the angular dependence of ultrasound backscatter.The Journal of the Acoustical Society of America · 2026Article
- Age-related differences in MRI signal intensity of the quadriceps and patellar tendons: Implications for ACL graft selection.Journal of experimental orthopaedics · 2026Article
- Tendon mechanobiology in the context of tendon biofabrication.Frontiers in bioengineering and biotechnology · 2025Review
- Guidelines for ex vivo mechanical testing of tendon.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023Review
- The Influence of Hip and Knee Joint Angles on Quadriceps Muscle-Tendon Unit Properties during Maximal Voluntary Isometric Contraction.International journal of environmental research and public health · 2023Article
- Aging and matrix viscoelasticity affect multiscale tendon properties and tendon derived cell behavior.Acta biomaterialia · 2022Article
- Polymer-Based Constructs for Flexor Tendon Repair: A Review.Polymers · 2022Review
- Age and Intrinsic Fitness Affect the Female Rotator Cuff Tendon Tissue.Biomedicines · 2022Article
- Review
- Structure, composition and fibril-reinforced poroviscoelastic properties of bovine knee ligaments and patellar tendon.Journal of the Royal Society, Interface · 2021Article
- Proceed with Caution: Mouse Deep Digit Flexor Tendon Injury Model.Plastic and reconstructive surgery. Global open · 2021Article
- Tendon Extracellular Matrix Assembly, Maintenance and Dysregulation Throughout Life.Advances in experimental medicine and biology · 2021Review
- Investigating the birth-related caudal maternal pelvic floor muscle injury: The consequences of low cycle fatigue damage.Journal of the mechanical behavior of biomedical materials · 2020Article
- Impact of Uniaxial Stretching on Both Gliding and Traction Areas of Tendon Explants in a Novel Bioreactor.International journal of molecular sciences · 2020Article
- Viscoelastic characteristics of the canine cranial cruciate ligament complex at slow strain rates.PeerJ · 2020Article
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6 authors at 5 institutions in 1 country.
Funding
Abstract
In tendon, type-I collagen assembles together into fibrils, fibers, and fascicles that exhibit a wavy or crimped pattern that uncrimps with applied tensile loading. This structural property has been observed across multiple tendons throughout aging and may play an important role in tendon viscoelasticity, response to fatigue loading, healing, and development. Previous work has shown that crimp is permanently altered with the application of fatigue loading. This opens the possibility of evaluating tendon crimp as a clinical surrogate of tissue damage. The purpose of this study was to determine how fatigue loading in tendon affects crimp and mechanical properties throughout aging and between tendon types. Mouse patellar tendons (PT) and flexor digitorum longus (FDL) tendons were fatigue loaded while an integrated plane polariscope simultaneously assessed crimp properties at P150 and P570 days of age to model mature and aged tendon phenotypes (N = 10-11/group). Tendon type, fatigue loading, and aging were found to differentially affect tendon mechanical and crimp properties. FDL tendons had higher modulus and hysteresis, whereas the PT showed more laxity and toe region strain throughout aging. Crimp frequency was consistently higher in FDL compared with PT throughout fatigue loading, whereas the crimp amplitude was cycle dependent. This differential response based on tendon type and age further suggests that the FDL and the PT respond differently to fatigue loading and that this response is age-dependent. Together, our findings suggest that the mechanical and structural effects of fatigue loading are specific to tendon type and age in mice. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 38:36-42, 2020.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.