Age-Related Decrease in Tyrosine Hydroxylase Immunoreactivity in the Substantia Nigra and Region-Specific Changes in Microglia Morphology in HIV-1 Tg Rats.
David R Goulding, Andrew Kraft, Peter R Mouton, Christopher A McPherson, Valeria Avdoshina, Italo Mocchetti, G Jean Harry
Article in Neurotoxicity research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
4 citing papers in PubMed, 7 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
7 authors at 3 institutions in 1 country.
David R GouldingComparative Medicine Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
Andrew KraftNational Toxicology Program Laboratory, National Institute of Environmental Health Sciences (NIEHS), P.O. Box 12233, MD E1-07, Research Triangle Park, NC, 27709, USA.
Peter R MoutonSRC Biosciences, Tampa, FL, USA.
Christopher A McPhersonNational Toxicology Program Laboratory, National Institute of Environmental Health Sciences (NIEHS), P.O. Box 12233, MD E1-07, Research Triangle Park, NC, 27709, USA.
Valeria AvdoshinaLaboratory of Preclinical Neurobiology, Department of Neuroscience, Georgetown University, Washington, D.C., USA.
Italo MocchettiLaboratory of Preclinical Neurobiology, Department of Neuroscience, Georgetown University, Washington, D.C., USA.
G Jean HarryNational Toxicology Program Laboratory, National Institute of Environmental Health Sciences (NIEHS), P.O. Box 12233, MD E1-07, Research Triangle Park, NC, 27709, USA. harry@niehs.nih.gov.ORCID http://orcid.org/0000-0002-0829-7318
National Institute of Environmental Health Sciences · USGeorgetown University · USEnvironmental Protection Agency · US
Funding
Environmentally Induced Alterations In Neuron And Glia Development and AgingZIAES021164 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI HARRY, GAYLIA JEAN · 2009 to 2021
$15.4M
Role of proBNDF and p75NTR in HIV-mediated Axonal/Dendritic DegenerationR01NS079172 · NINDS · GEORGETOWN UNIVERSITY · PI Italo Mocchetti · 2012 to 2026
$7.0M
Neuroimmunotoxicology: autoimmunity, viral, infectious aZ01ES101623 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI HARRY, GAYLIA JEAN · 2003 to 2008
$2.8M
Opioid withdrawal and microglia: synergistic effect with HIV-mediated neurodegeneration?R21NS102121 · NINDS · GEORGETOWN UNIVERSITY · PI AVDOSHINA, VALERIA, MOCCHETTI, ITALO · 2017 to 2018
$428k
Cellular and molecular mechanisms of gp120 neurotoxicityR21NS074916 · NINDS · GEORGETOWN UNIVERSITY · PI MOCCHETTI, ITALO · 2011 to 2012
$426k
Environment Effects and Development of Neuron and GliaZ01ES021164 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI HARRY, GAYLIA JEAN · 1997 to 2008
Animal models have been used to study cellular processes related to human immunodeficiency virus-1 (HIV-1)-associated neurocognitive disorders (HAND). The HIV-1 transgenic (Tg) rat expresses HIV viral genes except the gag-pol replication genes and exhibits neuropathological features similar to HIV patients receiving combined antiretroviral therapy (cART). Using this rat, alterations in dopaminergic function have been demonstrated; however, the data for neuroinflammation and glial reactivity is conflicting. Differences in behavior, tyrosine hydroxylase (TH) immunoreactivity, neuroinflammation, and glia reactivity were assessed in HIV-1 Tg male rats. At 6 and 12 weeks of age, rotarod performance was diminished, motor activity was not altered, and active avoidance latency performance and memory were diminished in HIV-1 Tg rats. TH
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Age-Related Decrease in Tyrosine Hydroxylase Immunoreactivity in the Substantia Nigra and Region-Specific Changes in Microglia Morphology in HIV-1 Tg Rats. · full record | OpenQuestion