Evidence map›Paper›PMID 31286393›Full record

ArticleMolecular biology reports2019

Lack of association between functional polymorphism of DNA repair genes (XRCC1, XPD) and clinical response in Indian chronic myeloid leukemia patients.

Somprakash Dhangar, Vinay Shanbhag, Chandrakala Shanmukhaiah, Babu Rao Vundinti

Abstract read
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In one paragraph

Article in Molecular biology reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. The Role of DNA Repair (Medicina (Kaunas, Lithuania) · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Somprakash DhangarDepartment of Cytogenetics, National Institute of Immunohaematology (ICMR), 13th Floor, New Multistoried Building, KEM Hospital Campus, Parel, Mumbai, 400012, India.
Vinay ShanbhagDepartment of Cytogenetics, National Institute of Immunohaematology (ICMR), 13th Floor, New Multistoried Building, KEM Hospital Campus, Parel, Mumbai, 400012, India.
Chandrakala ShanmukhaiahDepartment of Hematology, KEM Hospital, 10th Floor, New Multistoried Building, Parel, Mumbai, 400012, India.
Babu Rao VundintiDepartment of Cytogenetics, National Institute of Immunohaematology (ICMR), 13th Floor, New Multistoried Building, KEM Hospital Campus, Parel, Mumbai, 400012, India. vbaburao@hotmail.com.ORCID http://orcid.org/0000-0003-4783-2691
ICMR - National Institute of Immunohaemotology · IN

Funding

Indian Council of Medical Research core Grant
6 · The paper itself

Abstract

The resistance for the tyrosine kinase inhibitors in chronic myeloid leukemia (CML) occurs mainly due to BCR/ABL1 dependent and independent mechanisms. The defective DNA repair due to functional polymorphisms in DNA repair genes, might act as an etiological factor for leukemia progression. The study was carried out to understand the role of DNA repair genes (XRCC1, XPD) polymorphisms in Imatinib mesylate (IM) resistant CML patients. The study was carried out in total 87 CML patients (43 nonresponders-cases and 44 responders) who were treated with Imatinib. The treatment and follow-up was done according to European LeukemiaNet guidelines. The genotyping of selected SNPs were studied using RFLP and confirmed with Sanger sequencing (20%). The statistical analysis was performed using online tools (Socscistatistics and GraphPad InStat software). In our study no significant association was inferred between genotypes of DNA repair genes (XRCC1; rs1799782, rs25487, and XPD; rs13181) and complete cytogenetic response as well as molecular response. However there might be a possibility of association between XRCC1 Arg399Gln genotype AA/GA and cytogenetic response though it is statistically insignificant (p > 0.05). Though none of the genotypes of the DNA repair genes showed association with IM response, near association between XRCC1Arg399Gln genotype and cytogenetic response observed in our study. Hence, large sample size should be studied to establish the association of SNPs of DNA repair genes and IM response. Our study is a novel and important to explain the role of DNA repair genes polymorphisms in IM resistance.

Indexed as

DNA RepairAdolescentAdultAgedAntineoplastic AgentsChildDNA-Binding ProteinsDrug Resistance, NeoplasmFemaleGenetic Association StudiesGenetic Predisposition to DiseaseHumansImatinib MesylateIndiaLeukemia, Myelogenous, Chronic, BCR-ABL PositiveMaleAntineoplastic AgentsDNA-Binding ProteinsERCC2 protein, humanImatinib MesylateXeroderma Pigmentosum Group D ProteinX-ray Repair Cross Complementing Protein 1XRCC1 protein, humanChronic myeloid leukemia (CML)Clinical responseDNA repair genesDouble strand break (DSB)Imatinib mesylateSingle nucleotide polymorphisms (SNPs)

Identifiers

PMID31286393
OpenAlexW2960282602

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.