Evidence map›Paper›PMID 31286322›Full record

ArticleInvestigational new drugs2020

Autophagy inhibition potentiates ruxolitinib-induced apoptosis in JAK2

João Agostinho Machado-Neto, Juan Luiz Coelho-Silva, Fábio Pires de Souza Santos, Priscila Santos Scheucher, Paulo Vidal Campregher, Nelson Hamerschlak, Eduardo Magalhães Rego, Fabiola Traina

Abstract read
PubMed Publisher
In one paragraph

Article in Investigational new drugs, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Ruxolitinib reduces macrophage pyroptosis in aplastic anaemia.Clinical and experimental medicine · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

João Agostinho Machado-NetoDepartment of Medical Images, Hematology and Clinical Oncology, University of São Paulo at Ribeirão Preto Medical School, Av. Bandeirante, Ribeirão Preto, SP, 3900, Brazil.
Juan Luiz Coelho-SilvaDepartment of Medical Images, Hematology and Clinical Oncology, University of São Paulo at Ribeirão Preto Medical School, Av. Bandeirante, Ribeirão Preto, SP, 3900, Brazil.
Fábio Pires de Souza SantosCentro de Oncologia e Hematologia Familia Dayan-Daycoval, Hospital Israelita Albert Einstein São Paulo, São Paulo, Brazil.
Priscila Santos ScheucherDepartment of Medical Images, Hematology and Clinical Oncology, University of São Paulo at Ribeirão Preto Medical School, Av. Bandeirante, Ribeirão Preto, SP, 3900, Brazil.
Paulo Vidal CampregherCentro de Oncologia e Hematologia Familia Dayan-Daycoval, Hospital Israelita Albert Einstein São Paulo, São Paulo, Brazil.
Nelson HamerschlakCentro de Oncologia e Hematologia Familia Dayan-Daycoval, Hospital Israelita Albert Einstein São Paulo, São Paulo, Brazil.
Eduardo Magalhães RegoDepartment of Medical Images, Hematology and Clinical Oncology, University of São Paulo at Ribeirão Preto Medical School, Av. Bandeirante, Ribeirão Preto, SP, 3900, Brazil.
Fabiola TrainaDepartment of Medical Images, Hematology and Clinical Oncology, University of São Paulo at Ribeirão Preto Medical School, Av. Bandeirante, Ribeirão Preto, SP, 3900, Brazil. ftraina@fmrp.usp.br.
Universidade de São Paulo · BRHospital Israelita Albert Einstein · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

JAK2

Indexed as

AdultAgedAged, 80 and overApoptosisAutophagyFemaleHumansJanus Kinase 2MaleMiddle AgedMutationMyeloproliferative DisordersNitrilesPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktPyrazolesJAK2 protein, humanJanus Kinase 2NitrilesPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktPyrazolesPyrimidinesruxolitinibTOR Serine-Threonine KinasesApoptosisAutophagyChloroquineMyeloproliferative neoplasmsRuxolitinib

Identifiers

PMID31286322
OpenAlexW2957109629

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.