ArticlePediatric nephrology (Berlin, Germany)2019
Use of height-independent baseline creatinine imputation method with renal angina index.
Article in Pediatric nephrology (Berlin, Germany), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Cryptic and Overt Acute Kidney Injury Share Biomarker Characteristics in Pediatric Acute Respiratory Distress Syndrome.Critical care explorations · 2026Observational
- External Validation, Molecular Signatures, and Therapeutic Relevance of Pediatric Sepsis-Associated Acute Kidney Injury Subphenotypes.Critical care medicine · 2026Observational
- Urine NGAL adds to serum creatinine in predicting cefepime clearance in critically ill children at high risk of acute kidney injury.International journal of antimicrobial agents · 2026Article
- Acute renal angina index in pediatric emergency care: the hidden impact of baseline creatinine estimation.Pediatric nephrology (Berlin, Germany) · 2026Article
- A novel age-norm-capped baseline serum creatinine approach for acute kidney injury diagnosis in critically Ill children: a retrospective cohort study.Frontiers in pediatrics · 2026Article
- Vancomycin dosing in neonates: enhancing outcomes using population pharmacokinetics and simulation.Frontiers in antibiotics · 2025Article
- Fifteen-year temporal changes in rates of acute kidney injury among children in Denmark.Pediatric nephrology (Berlin, Germany) · 2024Article
- Real-Time Acute Kidney Injury Risk Stratification-Biomarker Directed Fluid Management Improves Outcomes in Critically Ill Children and Young Adults.Kidney international reports · 2023Article
- External validation of the modified sepsis renal angina index for prediction of severe acute kidney injury in children with septic shock.Critical care (London, England) · 2023Observational
- Derivation and evaluation of baseline creatinine equations for hospitalized children and adolescents: the AKI baseline creatinine equation.Pediatric nephrology (Berlin, Germany) · 2022Article
- Integration of the Renal Angina Index and Urine Neutrophil Gelatinase-Associated Lipocalin Improves Severe Acute Kidney Injury Prediction in Critically Ill Children and Young Adults.Kidney international reports · 2022Article
- Assessment of the renal angina index for the prediction of acute kidney injury in patients admitted to a European pediatric intensive care unit.Pediatric nephrology (Berlin, Germany) · 2021Observational
- Recalibration of the Renal Angina Index for Pediatric Septic Shock.Kidney international reports · 2021Article
- Re-evaluating Renal Angina Index: An Authentic, Evidence-Based Instrument for Acute Kidney Injury Assessment: Critical Appraisal.Frontiers in pediatrics · 2021Article
- Acute Kidney Injury: Diagnosis and Management.Indian journal of pediatrics · 2020Review
- PERSEVERE Biomarkers Predict Severe Acute Kidney Injury and Renal Recovery in Pediatric Septic Shock.American journal of respiratory and critical care medicine · 2020Observational
- Early Sequential Risk Stratification Assessment to Optimize Fluid Dosing, CRRT Initiation and Discontinuation in Critically Ill Children with Acute Kidney Injury: Taking Focus 2 Process Article.Journal of clinical trials · 2020Article
- Identifying critically ill children at high risk of acute kidney injury and renal replacement therapy.PloS one · 2020Observational
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Authors and funding
11 authors.
Funding
Abstract
backgroundThe Renal Angina Index (RAI) is a validated screening tool used at 12 h of pediatric intensive care unit (PICU) admission to predict severe acute kidney injury (AKI) on day 3 of PICU stay. A measured or height-imputed baseline serum creatinine (SCr) is required for AKI diagnosis and RAI calculation, yet these are often lacking. We assessed an age-based, height-independent baseline SCr calculation and compared the RAI values employing this method to their historical counterpart.
methodsAn electronic algorithm was implemented to generate RAI score for patients admitted to our PICU. We reviewed 157 consecutive patient records from May 2017, until we cumulated 100 with a valid RAI calculation. We compared RAI scores using the age-based SCr imputation method of Pottel to the historical RAI. Our primary outcome was a difference in the rate of RAI fulfillment (≥ 8) reclassification between methods.
resultsOf the first 100 patients, 27 had measured baseline SCr and 73 used height imputation. Only two patients had RAI reclassified with the Pottel method (one in each direction). Being small for age or older were associated with ≥ 25% overestimation of the baseline SCr in 20 patients with the Pottel method compared with height imputation. 15/157 patients had a falsely positive RAI due to lack of measured baseline SCr and height.
conclusionThe age-based method to estimate baseline SCr offers a viable height-independent alternative for RAI calculation. While less precise than a height-based approach, this lack of precision rarely leads to reclassification of patient RAI status.
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