Evidence map›Paper›PMID 31286230›Full record

SynthesisSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2019

Systematic review of anti-inflammatory agents for the management of oral mucositis in cancer patients and clinical practice guidelines.

Anura Ariyawardana, Karis Kin Fong Cheng, Abhishek Kandwal, Vanessa Tilly, Abdul Rahman Al-Azri, Dimitra Galiti, Karen Chiang, Anusha Vaddi, Vinisha Ranna, Ourania Nicolatou-Galitis and 4 more

Registry-linked trialAbstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05308732 (Phase I Study of Multiple Ascending Dose, to Investigate the Safety and Tolerability of the Use of Copaiba in Patients With Oral Cancer Submitted to Radiotherapy), which is not on this map. Cited by 51 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 6 pooled it
11.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05308732 phase1active not recruitingnot on this mapstarted 2021, after this paper: background citation

Phase I Study of Multiple Ascending Dose, to Investigate the Safety and Tolerability of the Use of Copaiba in Patients With Oral Cancer Submitted to Radiotherapy

TypeinterventionalSponsorInstituto Nacional de Cancer, BrazilRan2021 to 2026Enrolled20ConditionsHead and Neck Neoplasms, Mucositis Oral, Radiotherapy, ComplicationsArmsCopaiba
3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 6 syntheses or guidelines pooled it, 121 citations in OpenAlex.

  1. Pooled it
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  4. Anti-inflammatory mouthwashes for the prevention of oral mucositis in cancer therapy: an integrative review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
    Pooled it
  5. Prediction of mucositis risk secondary to cancer therapy: a systematic review of current evidence and call to action.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020
    Pooled it
  6. Guideline
  7. Trial
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  12. Cryopreventive temperatures prior to chemotherapy.Medical oncology (Northwood, London, England) · 2023
    Trial
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  14. Review
  15. Article
  16. Article
  17. Introducing equivalent and threshold doses in the assessment of medication-related osteonecrosis of the jaw risk: insights from a descriptive study in Iran.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Article
  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 11 institutions in 8 countries.

Anura AriyawardanaCollege of Medicine and Dentistry, James Cook University, Cairns, Australia. anura.ariyawardana@jcu.edu.au.ORCID http://orcid.org/0000-0002-4671-7045
Karis Kin Fong ChengAlice Lee Centre for Nursing Studies, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Abhishek KandwalDepartment of Dental Surgery, Cancer Research Institute, Himalayan Institute of Medical Sciences, Swami Rama Himalayn University, Dehradun, Uttarakhand, India.
Vanessa TillyDental Oncology Service, Instituto do Câncer do Estado de São Paulo, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Abdul Rahman Al-AzriDental and OMFS Department, Oral Pathology and Medicine, Al-Nahdha Hospital, Ministry of Health, Muscat, Oman.
Dimitra GalitiDental School, National and Kapodistrian University of Athens, Athens, Greece.
Karen ChiangPharmacy Department, St. Vincent's Hospital Melbourne, Fitzroy, Victoria, Australia.
Anusha VaddiOral Medicine, Eastman Institute for Oral Health, University of Rochester Medical Center, Rochester, NY, USA.
Vinisha RannaDepartment of Oral and Maxillofacial Surgery, The Mount Sinai Hospital, New York, NY, USA.
Ourania Nicolatou-GalitisDental School, National and Kapodistrian University of Athens, Athens, Greece.
Rajesh V LallaSection of Oral Medicine, University of Connecticut School of Dental Medicine, Farmington, CT, USA.
Paolo BossiDepartment of Medical and Surgical Specialties, Radiological Sciences and Public Health-Medical Oncology, ASST-Spedali Civili, University of Brescia, Brescia, Italy.
Sharon EladOral Medicine, Eastman Institute for Oral Health, University of Rochester Medical Center, Rochester, NY, USA.
Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society for Oral Oncology (MASCC/ISOO)
National and Kapodistrian University of Athens · GRUniversity of Rochester Medical Center · USMetro South Health · AUMinistry of Health · OMMount Sinai Hospital · USNational University of Singapore · SGSt Vincent's Hospital Melbourne · AUSwami Rama Himalayan University · INUniversidade de São Paulo · BRUniversity of Brescia · ITUniversity of Connecticut · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe aim of this systematic review was to update the clinical practice guidelines for the use of anti-inflammatory agents in the prevention and/or treatment of oral mucositis.

methodsA systematic review was conducted by the Multinational Association of Supportive Care in Cancer/ International Society of Oral Oncology (MASCC/ISOO) subcommittee on mucositis guideline update. The body of evidence for each intervention, in each cancer treatment setting, was assigned an evidence level. The findings were added to the database used to develop the clinical practice guidelines published in 2014. Based on the evidence level, one of the following three guideline determinations was possible: recommendation, suggestion, and no guidelines.

resultsA total of 11 new papers across five interventions were examined. The recommendation for the use of benzydamine mouthwash for the prevention of radiotherapy-induced mucositis remained unchanged. New suggestion for the use of the same for prevention of mucositis associated with chemoradiotherapy was made. No guideline was possible for any other anti-inflammatory agents due to inadequate and/or conflicting evidence.

conclusionsOf the anti-inflammatory agents studied for oral mucositis, the evidence supports the use of benzydamine mouthwash in the specific populations listed above. Additional well-designed research is needed on other (class of agents) interventions and in other cancer treatment settings.

Indexed as

Practice Guidelines as TopicAnti-Inflammatory AgentsAntineoplastic AgentsBenzydamineChemoradiotherapyHumansMucositisNeoplasmsStomatitisAnti-Inflammatory AgentsAntineoplastic AgentsBenzydamineAnti-inflammatory agentsCancerChemotherapyGuidelinesInterventionManagementOral mucositisRadiotherapy

Identifiers

PMID31286230
OpenAlexW2957093927

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.