Evidence map›Paper›PMID 31286228›Full record

SynthesisSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2019

Systematic review of photobiomodulation for the management of oral mucositis in cancer patients and clinical practice guidelines.

Yehuda Zadik, Praveen R Arany, Eduardo Rodrigues Fregnani, Paolo Bossi, Héliton Spindola Antunes, René-Jean Bensadoun, Luiz Alcino Gueiros, Alessandra Majorana, Raj G Nair, Vinisha Ranna and 8 more

5 registry-linked trialsOpen access · bronzeAbstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 163 papers, 19 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
163citing papers in PubMed, 19 pooled it
33.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05308732 phase1active not recruitingnot on this mapstarted 2021, after this paper: background citation

Phase I Study of Multiple Ascending Dose, to Investigate the Safety and Tolerability of the Use of Copaiba in Patients With Oral Cancer Submitted to Radiotherapy

TypeinterventionalSponsorInstituto Nacional de Cancer, BrazilRan2021 to 2026Enrolled20ConditionsHead and Neck Neoplasms, Mucositis Oral, Radiotherapy, ComplicationsArmsCopaiba
NCT06071637 phase3recruitingnot on this mapstarted 2023, after this paper: background citation

Low Power Laser Therapy As Prevention Of Oral Mucositis And Oropharyngeal Pain In Patients Undergoing Allogenetic Hematopoietic Stem Cell Transplantation.

TypeinterventionalSponsorInstituto Nacional de Cancer, BrazilRan2023 to 2027Enrolled84ConditionsHematopoietic Stem Cell Transplantation, Low-Level Light Therapy, StomatitisArmsDouble low-power laser therapy simultaneous applicated
NCT06217224 naunknown statusnot on this mapstarted 2022, after this paper: background citation

Evaluation of Prophylactic Photobiomodulation Therapy in Patients With Osteosarcoma Undergoing High Doses of Methotrexate

TypeinterventionalSponsorInstituto Nacional de Cancer, BrazilRan2022 to 2025Enrolled53ConditionsMucositis OralArmsPreventive photobiomodulation Therapy (PBMT)
NCT06623305 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Photobiomodulation Therapy for the Prevention of Mucositis in Pediatric Oncology Patients

TypeinterventionalSponsorMedical College of WisconsinRan2026 to 2027Enrolled50ConditionsMucositis OralArmsPhotobiomodulation for prevention arm, Photobiomodulation for exploratory arm
NCT06834685 narecruitingnot on this mapstarted 2025, after this paper: background citation

Evaluating Laser Photobiomodulation for the Treatment of Neuropathic Pain in Chemotherapy-induced Peripheral Neuropathy: a Randomized, Non-comparative, Placebo-controlled, Single-blinded, Phase II Clinical Trial in Cancer Patients

TypeinterventionalSponsorInstitut du Cancer de Montpellier - Val d'AurelleRan2025 to 2028Enrolled70ConditionsCancer Survivors, Peripheral Neuropathic PainArmsPhotobiomodulation sessions
3 · Its place in the literature

Who cites it

163 citing papers in PubMed, 19 syntheses or guidelines pooled it, 351 citations in OpenAlex.

  1. Photobiomodulation for oral mucositis in cancer care: prevention, clinical management, and evidence from randomized controlled trials.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
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  5. The supportive use of photobiomodulation on salivary glands: a narrative review and meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024
    Pooled it
  6. Impact of low-level laser therapy on the quality of life of patients with xerostomia undergoing head and neck radiotherapy: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
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  8. Efficacy of photobiomodulation in the treatment of oral mucositis in patients undergoing antineoplastic therapy: systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
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  13. Cost-effectiveness of photobiomodulation therapy for the prevention and management of cancer treatment toxicities: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021
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  15. Photobiomodulation in oral mucositis in patients with head and neck cancer: a systematic review and meta-analysis followed by a cost-effectiveness analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020
    Pooled it
  16. Prediction of mucositis risk secondary to cancer therapy: a systematic review of current evidence and call to action.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020
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  20. Photobiomodulation to prevent oral mucositis and physical function impairments after hematopoietic cell transplantation: POMFITT randomized trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Trial

103 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 16 institutions in 8 countries.

Yehuda ZadikDepartment of Oral Medicine, Oral and Maxillofacial Center, Medical Corps, Israel Defense Forces, Tel-Hashomer, Israel. Yehuda.Zadik@mail.huji.ac.il.
Praveen R AranyDepartment of Oral Biology and Biomedical Engineering, School of Dental Medicine, Engineering and Applied Sciences, University at Buffalo, 3435 Main Street, B36A Foster Hall, Buffalo, NY, 14214, USA. prarany@buffalo.edu.
Eduardo Rodrigues FregnaniOral Medicine Service, Hospital Sírio-Libanês São Paulo, São Paulo, Brazil.
Paolo BossiDepartment of Medical and Surgical Specialties, Radiological Sciences and Public Health - Medical Oncology, ASST-Spedali Civili, University of Brescia, Brescia, Italy.
Héliton Spindola AntunesClinical Research Division, National Cancer Institute of Brazil (INCA), Rio de Janeiro, Brazil.
René-Jean BensadounGérant, Responsable de Service, Centre de Haute Energie, Nice, France.
Luiz Alcino GueirosDepartamento de Clínica e Odontologia Preventiva, Universidade Federal de Pernambuco, Recife, PE, Brazil.
Alessandra MajoranaUniversity of Bresciam, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, Dental Clinic Oral Medicine, Brescia, Italy.
Raj G NairGriffith University and Gold Coast University Hospital, Southport, Australia.
Vinisha RannaDepartment of Oral and Maxillofacial Surgery, The Mount Sinai Hospital, New York, NY, USA.
Wim J E TissingDivision of Pediatric Oncology/Hematology/Immunology, Beatrix Childrens Hospital, University Medical Center Groningen, Groningen, The Netherlands.
Anusha VaddiOral Medicine, Eastman Institute for Oral Health, University of Rochester Medical Center, Rochester, NY, USA.
Rachel LubartDepartments of Physics and Chemistry, Bar-Ilan University, Ramat-Gan, Israel.
Cesar Augusto MiglioratiCollege of Dentistry, University of Florida, Gainesville, FL, USA.
Rajesh V LallaSection of Oral Medicine, University of Connecticut Health, Farmington, CT, USA.
Karis Kin Fong ChengYong Loo Lin School of Medicine, Clinical Research Centre, National University of Singapore, Level 2, Singapore, Singapore.
Sharon EladOral Medicine, Eastman Institute for Oral Health, University of Rochester Medical Center, Rochester, NY, USA.
Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISOO)
University of Brescia · ITBar-Ilan University · ILCentre de Haute Energie · FREastman Chemical Company (United States) · USGriffith University · AUHebrew University of Jerusalem · ILHospital Sírio-Libanês · BRInstituto Nacional do Câncer · BRMount Sinai Hospital · USNational University of Singapore · SGUConn Health · USUniversidade Federal de Pernambuco · BRUniversity at Buffalo, State University of New York · USUniversity Medical Center Groningen · NLUniversity of Florida · USUniversity of Rochester Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo systematically review the literature and update the evidence-based clinical practice guidelines for the use of photobiomodulation (PBM), such as laser and other light therapies, for the prevention and/or treatment of oral mucositis (OM).

methodsA systematic review was conducted by the Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society for Oral Oncology (MASCC/ISOO) using PubMed and Web of Science. We followed the MASCC methods for systematic review and guidelines development. The rigorously evaluated evidence for each intervention, in each cancer treatment setting, was assigned a level-of-evidence (LoE). Based on the LoE, one of the following guidelines was determined: Recommendation, Suggestion, or No Guideline Possible.

resultsRecommendations are made for the prevention of OM and related pain with PBM therapy in cancer patients treated with one of the following modalities: hematopoietic stem cell transplantation, head and neck (H&N) radiotherapy (without chemotherapy), and H&N radiotherapy with chemotherapy. For each of these modalities, we recommend 1-2 clinically effective protocols; the clinician should adhere to all parameters of the protocol selected. Due to inadequate evidence, currently, No Guideline Possible for treatment of established OM or for management of chemotherapy-related OM. The reported clinical settings were extremely variable, limiting data integration.

conclusionsThe evidence supports the use of specific settings of PBM therapy for the prevention of OM in specific patient populations. Under these circumstances, PBM is recommended for the prevention of OM. The guidelines are subject to continuous update based on new published data.

Indexed as

Practice Guidelines as TopicClinical ProtocolsHumansLow-Level Light TherapyMaleMucositisNeoplasmsStomatitisCancerChemotherapyEvidence-basedGuidelinesLaser therapyLEDLLLTLow-level laser therapyOral complications of cancer therapyOral mucositisPainPhotobiomodulationPhotobiostimulationPreventionRadiotherapyStomatitisTreatment

Identifiers

PMID31286228
OpenAlexW2957712509

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.