Evidence map›Paper›PMID 31286200›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2019

Radiomic features of glucose metabolism enable prediction of outcome in mantle cell lymphoma.

Marius E Mayerhoefer, Christopher C Riedl, Anita Kumar, Peter Gibbs, Michael Weber, Ilan Tal, Juliana Schilksy, Heiko Schöder

Abstract read
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
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  6. Association of [Diagnostics (Basel, Switzerland) · 2025
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  13. Semiquantitative 2-[Frontiers in medicine · 2024
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  16. Development and validation of a [European radiology · 2023
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  19. Impact of ComBat Harmonization on PET Radiomics-Based Tissue Classification: A Dual-Center PET/MRI and PET/CT Study.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Marius E MayerhoeferDepartment of Radiology, Molecular Imaging and Therapy Service, Memorial Sloan Kettering Cancer Center New York, 1275 York Ave, New York, NY, 10065, USA. mayerhom@mskcc.org.
Christopher C RiedlDepartment of Radiology, Molecular Imaging and Therapy Service, Memorial Sloan Kettering Cancer Center New York, 1275 York Ave, New York, NY, 10065, USA.
Anita KumarDepartment of Medicine, Lymphoma Service, Memorial Sloan Kettering Cancer Center New York, New York, NY, USA.
Peter GibbsDepartment of Radiology, Molecular Imaging and Therapy Service, Memorial Sloan Kettering Cancer Center New York, 1275 York Ave, New York, NY, 10065, USA.
Michael WeberDepartment of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria.
Ilan Tal, Haifa, Israel.
Juliana SchilksyDepartment of Radiology, Molecular Imaging and Therapy Service, Memorial Sloan Kettering Cancer Center New York, 1275 York Ave, New York, NY, 10065, USA.
Heiko SchöderDepartment of Radiology, Molecular Imaging and Therapy Service, Memorial Sloan Kettering Cancer Center New York, 1275 York Ave, New York, NY, 10065, USA.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

purposeTo determine whether [

methodsIncluded in this retrospective study were 107 treatment-naive MCL patients scheduled to receive CD20 antibody-based immuno(chemo)therapy. Standardized uptake values (SUV), total lesion glycolysis, and 16 co-occurrence matrix radiomic features were extracted from metabolic tumour volumes on pretherapy [

resultsSUVmean (OR 1.272, P = 0.013) and Entropy (heterogeneity of glucose metabolism; OR 1.131, P = 0.027) were significantly predictive of 2-year PFS: median areas under the curve were 0.72 based on the two radiomic features alone, and 0.82 with the addition of clinical/laboratory/biological data. Higher SUVmean in combination with higher Entropy (SUVmean >3.55 and entropy >3.5), reflecting high "metabolic risk", was associated with a poorer prognosis (median PFS 20.3 vs. 39.4 months, HR 2.285, P = 0.005). The best PFS prognostication was achieved using the MIPI-bm (MIPI-b and metabolic risk combined): median PFS 43.2, 38.2 and 20.3 months in the low-risk, intermediate-risk and high-risk groups respectively (P = 0.005).

conclusionIn MCL, the [

Indexed as

Image Processing, Computer-AssistedPositron Emission Tomography Computed TomographyAgedDisease-Free SurvivalFemaleGlucoseHumansLymphoma, Mantle-CellMalePrognosisRetrospective StudiesGlucoseFDGLymphomaPET/CTPrognosis

Identifiers

PMID31286200
PMCPMC6879438

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.