ArticleEuropean radiology2019
SyMRI detects delayed myelination in preterm neonates.
Article in European radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed, 36 citations in OpenAlex.
- Whole-tumor histogram analysis of synthetic MRI for the differentiation of benign and malignant soft-tissue tumors: a preliminary study.European radiology · 2025Article
- Quantitative MRI in Neuroimaging: A Review of Techniques, Biomarkers, and Emerging Clinical Applications.Brain sciences · 2025Review
- Brain tissue biomarker impact bone age in central precocious puberty more than hormones: a quantitative synthetic magnetic resonance study.Japanese journal of radiology · 2025Article
- Synthetic MRI study of brain volume and subcortical myelin in various Parkinson's disease motor subtypes.NPJ Parkinson's disease · 2025Article
- Synthetic MRI and MR Fingerprinting-Derived Relaxometry of Antenatal Human Brainstem Myelination: A Postmortem-Based Quantitative Imaging Study.AJNR. American journal of neuroradiology · 2024Article
- Multi-Dynamic-Multi-Echo-based MRI for the Pre-Surgical Determination of Sellar Tumor Consistency: a Quantitative Approach for Predicting Lesion Resectability.Clinical neuroradiology · 2024Article
- Quantifying myelin in neonates using magnetic resonance imaging: a systematic literature review.Clinical and experimental pediatrics · 2024Article
- Synthetic magnetic resonance-based relaxometry and brain volume: cutoff values for predicting neurocognitive outcomes in very preterm infants.Pediatric radiology · 2024Article
- Quantitative assessment of preoperative brain development in pediatric congenital heart disease patients by synthetic MRI.Insights into imaging · 2024Article
- T1-weighted fast fluid-attenuated inversion-recovery sequence (T1-FFLAIR) enables the visualization and quantification of fetal brain myelination in utero.European radiology · 2024Article
- Quantitative Magnetic Resonance Imaging for Neurodevelopmental Outcome Prediction in Neonates Born Extremely Premature-An Exploratory Study.Clinical neuroradiology · 2024Article
- Neurodevelopmental outcome in preterm infants with intraventricular hemorrhages: the potential of quantitative brainstem MRI.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Paramagnetic rim lesions lead to pronounced diffuse periplaque white matter damage in multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2023Article
- Quantitative myelin imaging with MRI and PET: an overview of techniques and their validation status.Brain : a journal of neurology · 2023Review
- Structural and functional imaging of brains.Science China. Chemistry · 2023Review
- [Differential diagnosis of benign and malignant breast lesions using quantitative synthetic magnetic resonance imaging].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2022Article
- Different from the Beginning: WM Maturity of Female and Male Extremely Preterm Neonates-A Quantitative MRI Study.AJNR. American journal of neuroradiology · 2022Article
- Mapping Human Fetal Brain Maturation In Vivo Using Quantitative MRI.AJNR. American journal of neuroradiology · 2021Article
- Validity of SyMRI for Assessment of the Neonatal Brain.Clinical neuroradiology · 2021Article
- Impact of Prematurity on the Tissue Properties of the Neonatal Brain Stem: A Quantitative MR Approach.AJNR. American journal of neuroradiology · 2021Article
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9 authors at 1 institution in 1 country.
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Abstract
objectivesThe software "SyMRI" generates different MR contrasts and characterizes tissue properties based on a single acquisition of a multi-dynamic multi-echo (MDME)-FLAIR sequence. The aim of this study was to assess the applicability of "SyMRI" in the assessment of myelination in preterm and term-born neonates. Furthermore, "SyMRI" was compared with conventional MRI.
methodsA total of 30 preterm and term-born neonates were examined at term-equivalent age using a standardized MRI protocol. MDME sequence (acquisition time, 5 min, 24 s)-based post-processing was performed using "SyMRI". Myelination was assessed by scoring seven brain regions on quantitative T1-/T2-maps, generated by "SyMRI" and on standard T1-/T2-weighted images, acquired separately. Analysis of covariance (ANCOVA) (covariate, gestational age (GA) at MRI (GAMRI)) was used for group comparison.
resultsIn 25/30 patients (83.3%) (18 preterm and seven term-born neonates), "SyMRI" acquisitions were successfully performed. "SyMRI"-based myelination scores were significantly lower in preterm compared with term-born neonates (ANCOVA: T1: F(1, 22) = 7.420, p = 0.012; T2: F(1, 22) = 5.658, p = 0.026). "SyMRI"-based myelination scores positively correlated with GAMRI (T1: r = 0.662, n = 25, p ≤ 0.001; T2: r = 0.676, n = 25, p ≤ 0.001). The myelination scores based on standard MRI did not correlate with the GAMRI. No significant differences between preterm and term-born neonates were detectable.
conclusions"SyMRI" is a highly promising MR technique for neonatal brain imaging. "SyMRI" is superior to conventional MR sequences in the visual detection of delayed myelination in preterm neonates. KEY POINTS: • By providing multiple MR contrasts, "SyMRI" is a time-saving method in neonatal brain imaging. • Differences concerning the myelination in term-born and preterm infants are visually detectable on T1-/T2-weighted maps generated by "SyMRI". • "SyMRI" allows a faster and more sensitive assessment of myelination compared with standard MR sequences.
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