ArticleEuropean radiology2019
Alterations of white matter network in patients with left and right non-lesional temporal lobe epilepsy.
Article in European radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Impact of laterality on seizure duration in mesial temporal lobe epilepsy with hippocampal sclerosis.Epilepsy & behavior reports · 2026Article
- Morphometric Similarity Loss and Gray Matter Atrophy Align with Neurotransmitter and Mitochondrial Maps in Drug-Resistant Epilepsy.Neuropsychiatric disease and treatment · 2026Article
- Imaging and Stereotactic Electroencephalography Functional Networks to Guide Epilepsy Surgery.Neurosurgery clinics of North America · 2024Review
- Abnormal white matter structural network topological property in patients with temporal lobe epilepsy.CNS neuroscience & therapeutics · 2024Article
- Structural alterations of the salience network in patients with insular glioma.Brain and behavior · 2023Article
- Study of the microstructure of brain white matter in medial temporal lobe epilepsy based on diffusion tensor imaging.Brain and behavior · 2023Article
- Changes in the Brain in Temporal Lobe Epilepsy with Unilateral Hippocampal Sclerosis: An Initial Case Series.Healthcare (Basel, Switzerland) · 2022Article
- Temporal lobe epilepsy lateralisation and surgical outcome prediction using diffusion imaging.Journal of neurology, neurosurgery, and psychiatry · 2022Article
- Topological Characteristics Associated with Intraoperative Stimulation Related Epilepsy of Glioma Patients: A DTI Network Study.Brain sciences · 2021Article
- Review
- Depressive and Anxiety Symptoms Are Predictors of Seizure Recurrence in Adults With Newly Diagnosed Epilepsy.Frontiers in psychiatry · 2021Article
- Machine Learning-Derived Multimodal Neuroimaging of Presurgical Target Area to Predict Individual's Seizure Outcomes After Epilepsy Surgery.Frontiers in cell and developmental biology · 2021Article
- Abnormal Static and Dynamic Functional Connectivity in Left and Right Temporal Lobe Epilepsy.Frontiers in neuroscience · 2021Article
- Impaired Cognitive Abilities in Siblings of Patients with Temporal Lobe Epilepsy.Neuropsychiatric disease and treatment · 2020Article
- Reduction of bias in the evaluation of fractional anisotropy and mean diffusivity in magnetic resonance diffusion tensor imaging using region-of-interest methodology.Scientific reports · 2019Article
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Authors and funding
5 authors.
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Abstract
objectivesThe goal of this study was to investigate alterations of white matter (WM) network in patients with left non-lesional temporal lobe epilepsy (nl-TLE) and right nl-TLE to assess the relationship between the white matter network properties and clinical parameters.
methodsT1 magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) were acquired for 45 participants, including 30 nl-TLE patients (13 left, 17 right) and 15 healthy controls. Diffusion tensor tractography was computed to model the WM structural network. The topologic properties of the WM network were obtained by graph theoretical analysis, and the between-group differences in global and nodal properties of the WM network were examined by network-based statistical analysis (NBS). The relationship between WM network properties and clinical parameters was assessed by Pearson's correlation analysis.
resultsNBS results indicated that patients with left and right nl-TLE experienced distinct changes of WM nodal and global network properties compared with HCs. Positive correlation coefficients were found in several regions. The structural disruptions of networks in the two nl-TLE groups were observed to be different in distribution and severity.
conclusionsThis study provides evidence for changes of the WM network topological properties and structural connectivity in nl-TLE patients, which provide useful insights for the understanding of disease mechanisms of TLE and improving treatment outcomes for nl-TLE. KEY POINTS: • This study aims to investigate alterations of white matter (WM) network in patients with non-lesional temporal lobe epilepsy (nl-TLE). • Network-based statistical analysis results indicated that patients with left and right nl-TLE experienced distinct changes of WM nodal and global network properties compared with healthy controls. • This study provides useful insights for the understanding of disease mechanisms of TLE and improving treatment outcomes for nl-TLE.
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