Evidence map›Paper›PMID 31286154›Full record

ArticleDiabetologia2019

CD40-targeted peptide proposed for type 1 diabetes therapy lacks relevant binding affinity to its cognate receptor. Reply to Pagni PP, Wolf A, Lo Conte M et al [letter].

Gisela M Vaitaitis, Michael H Olmstead, Dan M Waid, Jessica R Carter, David H Wagner

Abstract readLetterComment
In one paragraph

Article in Diabetologia, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. CD40-targeting KGYYDiabetologia · 2019
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Gisela M VaitaitisWebb-Waring Center, University of Colorado Anschutz Medical Campus, 12850 East Montview Boulevard, C322, Aurora, CO, USA.
Michael H Olmstead, Aurora, USA.
Dan M WaidWebb-Waring Center, University of Colorado Anschutz Medical Campus, 12850 East Montview Boulevard, C322, Aurora, CO, USA.
Jessica R CarterWebb-Waring Center, University of Colorado Anschutz Medical Campus, 12850 East Montview Boulevard, C322, Aurora, CO, USA.
David H WagnerWebb-Waring Center, University of Colorado Anschutz Medical Campus, 12850 East Montview Boulevard, C322, Aurora, CO, USA. david.wagner@ucdenver.edu.

Funding

Discovering the Mechanism of Action of a peptide drug, OPT101, that targets CD40 mediated inflammation in type 1 diabetesR01DK131196 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI WAGNER, DAVID H. · 2022 to 2025
$1.7M
Development of a Clinical Screening Platform for Type 1 DiabetesR42DK115296 · NIDDK · OP-T-MUNE, INC. · PI WAGNER, DAVID H. · 2017 to 2019
$1.6M
NIDDK NIH HHS R01 DK131196NIDDK NIH HHS R42 DK115296
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Diabetes Mellitus, Type 1AnimalsCD40 AntigensCD40 LigandMiceMice, Inbred NODPeptidesCD40 AntigensCD40 LigandPeptidesAutoimmunityCD154CD40TherapeuticType 1 diabetes

Identifiers

PMID31286154
PMCPMC6679809

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.