Evidence map›Paper›PMID 31286008›Full record

ArticleMovement disorders clinical practice2019

Syringomyelia-Associated Dystonia: Case Series, Literature Review, and Novel Insights.

Eoin Mulroy, Bettina Balint, Anna Latorre, Sebastian Schreglmann, Elisa Menozzi, Kailash P Bhatia

Open access · bronzeAbstract readCase Reports
In one paragraph

Article in Movement disorders clinical practice, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. A case of IgG4-related spinal pachymeningitis with a large spinal cord cavity: case report and updated systematic review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Pooled it
  2. Article
  3. Article
  4. Cervical dystonia in a patient with cervical hydromyelic cavity.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Eoin MulroyDepartment of Clinical and Movement Neurosciences UCL Queen Square Institute of Neurology London United Kingdom.
Bettina BalintDepartment of Clinical and Movement Neurosciences UCL Queen Square Institute of Neurology London United Kingdom.
Anna LatorreDepartment of Clinical and Movement Neurosciences UCL Queen Square Institute of Neurology London United Kingdom.ORCID https://orcid.org/0000-0001-7103-5209
Sebastian SchreglmannDepartment of Clinical and Movement Neurosciences UCL Queen Square Institute of Neurology London United Kingdom.
Elisa MenozziDepartment of Clinical and Movement Neurosciences UCL Queen Square Institute of Neurology London United Kingdom.
Kailash P BhatiaDepartment of Clinical and Movement Neurosciences UCL Queen Square Institute of Neurology London United Kingdom.ORCID https://orcid.org/0000-0001-8185-286X
National Hospital for Neurology and Neurosurgery · GBHeidelberg University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSyringomyelia has previously been suggested as a potential trigger of secondary dystonia. However, a definite causal relationship between the conditions remains to be established. We describe 4 cases of syrinx-associated dystonia, review past literature on the subject, and propose novel pathophysiological insights into this association.

methodsWe reviewed demographic, clinical, and neuroradiological features in 4 cases of syrinx-associated dystonia. A retrospective review of previously published literature on the subject was also conducted.

resultsPatients with syrinx-associated dystonia were younger than those with primary dystonia. None had sensory gestes. Syringomyelia frequently involved the cervical cord. Arnold-Chiari type 1 malformation was a common finding. Some patients responded to botulinum toxin and syrinx decompression.

conclusionFurther work is needed to clearly establish the correlation between syringomyelia and dystonia. However, plausibly, syrinx-related disruption of the dystonia network (through alterations in sensory inputs, loss of inhibition and cerebellar abnormalities) could explain the association.

Indexed as

dystoniasensorimotor integrationsyringomyelia

Identifiers

PMID31286008
PMCPMC6592788
OpenAlexW2940260461

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.