ArticleJournal of thoracic disease2019
Use of ulinastatin was associated with reduced mortality in critically ill patients with sepsis.
Article in Journal of thoracic disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 11 citations in OpenAlex.
- Efficacy and Safety of Ulinastatin in Post-traumatic Sepsis: A Randomized Controlled Trial.Drugs in R&D · 2025Trial
- Ulinastatin protects against sepsis‑induced myocardial injury by inhibiting NLRP3 inflammasome activation.Molecular medicine reports · 2021Article
- [Neonatal capillary leak syndrome].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2020Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUlinastatin has anti-inflammatory properties and could potentially benefit critically ill septic patients. Nevertheless, clinical studies have yielded conflicting results. The present study examined the efficacy of ulinastatin in intensive care unit (ICU) patients with sepsis and/or septic shock.
methodsAll septic patients admitted to the ICU of Wuhu No. 2 People's Hospital between 2014 and 2017 were screened for potential eligibility for this retrospective study. The primary outcome was 28-day mortality, and its correlation with ulinastatin was assessed using multiple logistic regression models.
resultsThe study included 263 patients, with an overall 28-day mortality of 38%. Patients receiving ulinastatin showed significantly lower mortality than the control patients (31%
conclusionsTreatment with ulinastatin was associated with a decrease in 28-day mortality in critically ill septic patients.
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Registered trials
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