Evidence map›Paper›PMID 31285841›Full record

ArticleFuture science OA2019

Noninvasive imaging methods for evaluating cardiovascular involvement in patients with rheumatoid arthritis before and after anti-TNF drug treatment.

Fabiola Atzeni, Luigi Gianturco, Laura Boccassini, Piercarlo Sarzi-Puttini, Gianluca Bonitta, Maurizio Turiel

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Future science OA, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Re: ID f1459919-55b0-4cf8-8c61-369db603bc92 echocardiography in collagen diseases.The international journal of cardiovascular imaging · 2025
    Review
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Fabiola AtzeniRheumatology Unit, Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
Luigi GianturcoCardiology Unit, Beato Matteo Hospital, GSD Hospitals, Vigevano, Pavia, Italy.
Laura BoccassiniRheumatology Unit, ASST Fatebenefratelli-Sacco, University of Milan, Italy.
Piercarlo Sarzi-PuttiniRheumatology Unit, ASST Fatebenefratelli-Sacco, University of Milan, Italy.
Gianluca BonittaRheumatology Unit, Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
Maurizio TurielIRCCS Orthopedic Institute Galeazzi, Milan, Italy.
University of Messina · ITASST Fatebenefratelli Sacco · ITIstituto Ortopedico Galeazzi · ITUniversity of Milan · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo use 2D speckle-tracking echocardiography, and conventional and tissue Doppler echocardiography to detect subclinical left ventricular myocardial dysfunction in patients with rheumatoid arthritis (RA).

methodsThirty RA outpatients were assessed before and after 18 months of treatment with anti-TNF drugs, along with 30 healthy controls. Cardiovascular risk was assessed by means of ultrasound carotid assessment and comprehensive echocardiographic evaluation (conventional and speckle-tracking calculation).

resultsThe speckle-tracking analyses were significantly different between the two groups, with global longitudinal strain deformation in the apical four-chamber view being significantly lower in the RA patients (median: 18.78%, interquartile range [IQR]: 15.80-20.82% vs 20.16%, IQR: 19.03-21.89%; [p < 0.05]). After 18 months of biological treatment, global longitudinal strain showed a significant improvement (18.78%, IQR: 15.80-20.82 vs 19.24%, IQR: 18.23-19.98; [p < 0.01]), such as for DAS28 (4.80, IQR: 4.65-5.22 vs 2.78; IQR: 2.52-2.99; [p < 0.01]).

conclusionSpeckle-tracking echocardiography showed that left ventricular myocardial longitudinal strain was impaired in the RA patients.

Indexed as

cardiovascular diseasecardiovascular riskcarotid ultrasounddisease activityechocardiographymyocardial alterationsnoninvasive methodsrheumatoid arthritisspeckle tracking echocardiographyventricular alterations

Identifiers

PMID31285841
PMCPMC6609891
OpenAlexW2950921429

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.