The Genotype Frequency of CYP2C19 Enzyme after Liver Transplantation.

P Badiee, Z Hashemizadeh, S A Malek-Hosseini, B Geramizadeh

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Article in International journal of organ transplantation medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 authors at 1 institution in 1 country.

P BadieeProf. Alborzi Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Z HashemizadehDepartment of Organ Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

S A Malek-HosseiniDepartment of Organ Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

B GeramizadehDepartment of Pathology, Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Shiraz University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLiver transplant recipients are treated with various drugs, the metabolism of which is dependent on the cytochrome P450 polymorphic genotype.

objectiveTo identify the polymorphic variety of CYP2C19 genotype in liver allograft before and after transplantation.

methodsThe study was conducted on 88 liver recipients. The CYP2C19 genotypes in donors and recipients were the same in 32 and different in 56 recipients. Extracted genomic DNA from the leukocytes and liver graft tissues were analyzed by TaqMan SNP genotyping assay. The distributions of homozygote, heterozygote, poor and ultra-rapid metabolizers' genotypes were investigated in both groups.

resultsThe distributions of CYP2C19 genotypes before transplantation in the blood and liver graft were within the normal range. After transplantation, in patients with different CYP2C19 genotype in donors and recipients, the genotypes of homozygote and ultra-rapid metabolizers were significantly decreased (p=0.024); the heterozygotes and poor metabolizer genotypes were significantly increased (p=0.017).

conclusionThe variety in CYP2C19 genotyping must be considered in patients with different genotypes in donor and recipients to predict the dosage regimens, optimize the treatment and decrease toxicity.

Indexed as

CYP2C19Cytochrome P450GenotypeLiver transplantationPoor metabolizerUltra-rapid metabolizer

Identifiers

PMID31285806

PMCPMC6604758

OpenAlexW2993482911

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