ArticleNature medicine2019
Delayed childhood neurodevelopment and neurosensory alterations in the second year of life in a prospective cohort of ZIKV-exposed children.
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Article in Nature medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 170 papers, 4 of them syntheses that pooled it.
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0cells of the map it votes in
170citing papers in PubMed, 4 pooled it
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
170 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Neurodevelopment in Normocephalic Children Exposed to Zika Virus in Utero with No Observable Defects at Birth: A Systematic Review with Meta-Analysis.International journal of environmental research and public health · 2022Pooled it
- Measuring the global burden of chikungunya and Zika viruses: A systematic review.PLoS neglected tropical diseases · 2021Pooled it
- Time to Evaluate the Clinical Repercussions of Zika Virus Vertical Transmission? A Systematic Review.Frontiers in psychiatry · 2021Pooled it
- Health outcomes associated with Zika virus infection in humans: a systematic review of systematic reviews.BMJ open · 2019Pooled it
- Improving neurodevelopment in Zika-exposed children: A randomized controlled trial.PLoS neglected tropical diseases · 2022Trial
- Spondweni virus infection in pregnant rhesus macaques causes placental pathology without apparent fetal harm.bioRxiv : the preprint server for biology · 2026Article
- iPLA2β-dependent phospholipid remodeling drives ZIKV-induced neuroinflammation and neurological injury.Journal of neuroinflammation · 2026Article
- Cortical Auditory Neural Responses to Speech and Communicative Functioning in Normocephalic Children With Prenatal Exposure to the Zika Virus.Ear and hearing · 2026Article
- ZIKV envelope protein is a strong blocker of early directional differentiation in the neural lineage.Communications biology · 2026Article
- Cardiac findings in infants with in utero exposure to Zika virus - a follow up longitudinal study.PLoS neglected tropical diseases · 2026Article
- Prenatal Zika virus exposure disrupts social-emotional development and cortical visual function in infant macaques.Nature communications · 2026Article
- Viral threats to pregnancy: Global health risks in the era of pandemics.Advances in virus research · 2026Review
- Inapparent maternal ZIKV infection impacts fetal brain development and postnatal behavior.PLoS pathogens · 2026Article
- Zika virus infection in early pregnancy increases the likelihood of persistent neutralizing antibodies.PLoS neglected tropical diseases · 2026Article
- Trimester of maternal SARS-CoV-2 infection differentially predicts newborn size in the COVID-19 Mother Baby Outcomes (COMBO) cohort.Pediatric research · 2026Article
- DISC1 Protects Against Zika Virus Infection and Long-Term Neurological Damage Through AMPK-mTOR-Mediated Autophagy.Nature communications · 2025Article
- Defective Neural Stem and Progenitor Cell Proliferation in Neurodevelopmental Disorders.Journal of developmental biology · 2025Review
- School-age child neurodevelopment following antenatal Zika virus exposure.Pediatric research · 2025Article
- Prenatal exposure to Zika virus shapes offspring neutrophil function in a sex-specific manner.Nature communications · 2025Article
- Academic and social-behavioral assessment in a prospective cohort of normocephalic school-aged children with antenatal Zika virus exposure.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2025Article
110 more citing papers are in PubMed but not listed here.
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Authors and funding
28 authors.
Karin Nielsen-SainesDavid Geffen UCLA School of Medicine, CA, Los Angeles, USA. knielsen@mednet.ucla.edu.ORCID http://orcid.org/0000-0002-1742-5211
Patrícia BrasilFundação Oswaldo Cruz, Rio de Janeiro, Brazil.
Tara KerinDavid Geffen UCLA School of Medicine, CA, Los Angeles, USA.
Zilton VasconcelosFundação Oswaldo Cruz, Rio de Janeiro, Brazil.ORCID http://orcid.org/0000-0002-2193-2224
Claudia Raja GabagliaBiomedical Research Institute of Southern California, CA, Oceanside, USA.
Luana DamascenoFundação Oswaldo Cruz, Rio de Janeiro, Brazil.
Marcos PoneFundação Oswaldo Cruz, Rio de Janeiro, Brazil.
Liege M Abreu de CarvalhoFundação Oswaldo Cruz, Rio de Janeiro, Brazil.
Sheila M PoneFundação Oswaldo Cruz, Rio de Janeiro, Brazil.
Andrea A ZinFundação Oswaldo Cruz, Rio de Janeiro, Brazil.
Irena TsuiDavid Geffen UCLA School of Medicine, CA, Los Angeles, USA.
Tania Regina S SallesFundação Oswaldo Cruz, Rio de Janeiro, Brazil.
Denise Cotrim da CunhaFundação Oswaldo Cruz, Rio de Janeiro, Brazil.
Roozemerie Pereira CostaFundação Oswaldo Cruz, Rio de Janeiro, Brazil.
Jociele MalacarneFundação Oswaldo Cruz, Rio de Janeiro, Brazil.
Ana Beatriz ReisFundação Oswaldo Cruz, Rio de Janeiro, Brazil.
Renata Hydee HasueFaculty of Medicine, University of São Paulo, São Paulo, Brazil.
Carolina Y P AizawaFaculty of Medicine, University of São Paulo, São Paulo, Brazil.
Fernanda F GenovesiFaculty of Medicine, University of São Paulo, São Paulo, Brazil.
Christa EinspielerMedical University of Graz, Graz, Austria.
Peter B MarschikMedical University of Graz, Graz, Austria.ORCID http://orcid.org/0000-0001-8932-0980
José Paulo PereiraFundação Oswaldo Cruz, Rio de Janeiro, Brazil.
Stephanie L GawUCSF School of Medicine, CA, San Francisco, USA.
Kristina AdachiDavid Geffen UCLA School of Medicine, CA, Los Angeles, USA.
James D CherryDavid Geffen UCLA School of Medicine, CA, Los Angeles, USA.
Zhiheng XuState Key Laboratory of Molecular Developmental Biology, CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.ORCID http://orcid.org/0000-0002-4809-2851
Genhong ChengDavid Geffen UCLA School of Medicine, CA, Los Angeles, USA.
Maria Elisabeth MoreiraFundação Oswaldo Cruz, Rio de Janeiro, Brazil. bebethiff@gmail.com.ORCID http://orcid.org/0000-0002-2034-0294
Funding
Virology CoreP30AI028697 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MITSUYASU, RONALD T. · 1991 to 2018
$39.9MGenetic evolution, pathogenesis and immune responses in mother to child transmission of ZIKVR01AI140718 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHENG, GENHONG, JUNG, JAE U · 2018 to 2022
$3.8MPlacental malaria: The role of inflammation at the maternal-fetal interfaceK08AI141728 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GAW, STEPHANIE LINA · 2019 to 2023
$950kViral kinetics, immunity and transmission of ZIKV: an exploratory analysis in preparation for vaccine developmentR21AI129534 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BRASIL, PATRICIA, NIELSEN, KARIN · 2017 to 2018
$378kOpthalmic Manifestations of Congenital Zika Virus InfectionR21EY028318 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BRASIL, PATRICIA, NIELSEN, KARIN · 2017 to 2018
$373kNEI NIH HHS R21 EY028318NIAID NIH HHS K08 AI141728NIAID NIH HHS P30 AI028697NIAID NIH HHS R01 AI140718NIAID NIH HHS R21 AI129534NICHD NIH HHS L30 HD093159
Abstract
We report neurodevelopmental outcomes in 216 infants followed since the time of PCR-confirmed maternal Zika virus (ZIKV) infection in pregnancy during the Rio de Janeiro epidemic of 2015-2016 (refs.
Indexed as
AdultAutism Spectrum DisorderChild, PreschoolFemaleHearingHumansInfantInfant, NewbornMaleMicrocephalyNeurodevelopmental DisordersPregnancyPregnancy Complications, InfectiousProspective StudiesSensation DisordersVision, Ocular
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.